Medicine and Health Sciences Commons^™

A Bdnf Coding Variant Is Associated With The Neo Personality Inventory Domain Neuroticism, A Risk Factor For Depression, Srijan Sen, Randolph M. Nesse, Scott F. Stoltenberg, Sheng Li, Lillian Gleiberman, Aravinda Chakravarti, Alan B. Weber, Margit Burmeister

Department of Psychology: Faculty Publications

Genetic factors influence vulnerability to depression (Sullivan et al, 2000), but no specific genes have been definitively implicated. One promising approach is to determine whether variations in specific (candidate) genes are associated not with disease per se, but with traits, such as personality factors, that are themselves associated with risk for the disorder (Lander and Schork, 1994; Stoltenberg and Burmeister, 2000). Often such traits have a higher heritability than the disease status (Almasy and Blangero, 2001). Neuroticism, as measured by the NEO personality inventory (NEO-PI) (Costa and McCrae, 1997), a psychometrically sound and widely used instrument, is one such trait. …