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Antipsychotic; lurasidone; relapse; schizophrenia; tolerability; weight gain
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Schizophrenia Relapse, Patient Considerations, And Potential Role Of Lurasidone, Leslie L. Citrome
Schizophrenia Relapse, Patient Considerations, And Potential Role Of Lurasidone, Leslie L. Citrome
NYMC Faculty Publications
When treating persons with schizophrenia, delaying time to relapse is a main goal. Antipsychotic medication has been the primary treatment approach, and there are a variety of different choices available. Lurasidone is a second-generation (atypical) antipsychotic agent that is approved for the treatment of schizophrenia and bipolar depression. Three long-term studies of lurasidone have examined time to relapse in persons with schizophrenia, including a classic placebo-controlled randomized withdrawal study and two 12-month active comparator studies (vs risperidone and vs quetiapine extended-release). Lurasidone 40-80 mg/d evidenced superiority over placebo (number needed to treat [NNT] vs placebo for relapse, 9). Lurasidone 40-160 …