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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
The Effects Of Pre- And Postnatal Administration Of Propionic Acid And Lipopolysaccharide On The Behaviour Of Adolescent Male And Female Rats, Kelly A. Foley
The Effects Of Pre- And Postnatal Administration Of Propionic Acid And Lipopolysaccharide On The Behaviour Of Adolescent Male And Female Rats, Kelly A. Foley
Electronic Thesis and Dissertation Repository
The gut microbiome plays an important role in immune functioning and neurodevelopment. Altered microbiome composition, leading to short chain fatty acid, and/or immune system dysfunction has been observed in children with autism spectrum disorders (ASD). This thesis describes the developmental influence of prenatal exposure to propionic acid (PPA), a metabolic fermentation product of enteric bacteria, or prenatal exposure to lipopolysaccharide (LPS), a bacterial mimetic and product of enteric bacteria, on a range of behaviours in male and female neonatal, adolescent and adult rats. Study one evaluated the effects of prenatal PPA and LPS, and postnatal PPA, on developmental milestones in …
Theory Of Mind And The Ability To Make Emotional Inferences Among Children With High-Functioning Autism Spectrum Disorders, Abigail Leibovitch
Theory Of Mind And The Ability To Make Emotional Inferences Among Children With High-Functioning Autism Spectrum Disorders, Abigail Leibovitch
Open Access Dissertations
Perspective-taking skills are central to the successful navigation of social situations. Children need perspective-taking skills to help them correctly interpret different cues and accurately assess social situations so they can determine how to best respond. Children with Autism Spectrum Disorders (ASD) exhibit marked impairments in this area. In order to develop successful social skills interventions for this population, it is critical that we have a strong understanding of the nature of their deficits. While there is robust evidence that children with ASD experience difficulty making inferences about the beliefs of others, research on their ability to infer emotions has had …
Anxiety Symptoms In Individuals With High Functioning Autism, Jane C. Kelleher
Anxiety Symptoms In Individuals With High Functioning Autism, Jane C. Kelleher
Honors Scholar Theses
Research indicates a complicated relationship between anxiety disorders and autism spectrum disorders (ASDs). The current study examined the relationship between anxiety symptoms and ASD in 30 Optimal Outcome (OO) individuals, 33 High Functioning Autism (HFA) individuals, and 34 Typically Developing (TD) individuals. The groups were compared on the K-SADS measure of anxiety symptoms. The HFA group presented greater anxiety than both the OO and TD groups, and the OO and TD groups only differed on one anxiety symptom. Across all three groups, there was a significant association between greater anxiety symptoms and a higher level of social and communicative impairment. …
Magnetic Resonance Imaging Of Brain Tissue Abnormalities: Transverse Relaxation Time In Autism And Tourette Syndrome And Development Of A Novel Whole-Brain Myelin Mapping Technique, Yann Gagnon
Electronic Thesis and Dissertation Repository
The transverse relaxation time (T2) is a fundamental parameter of magnetic resonance imaging sensitive to tissue microstructure and water content, thus offering a non-invasive approach to evaluate abnormalities of brain tissue in-vivo. Prevailing hypotheses of two childhood psychiatric disorders were tested using quantitative T2 imaging and automated region of interest (ROI) analyses. In autism, the under-connectivity theory, which proposes aberrant connectivity within white matter (WM) was assessed, finding T2 to be eleveted in the frontal and parietal lobes, while dividing whole brain data into neurodevelopmentally relevant WM ROIs found increased T2 in bridging and radiate WM. In Tourette syndrome, tissue …
Age-Dependent Decrease And Alternative Splicing Of Methionine Synthase Mrna In Human Cerebral Cortex And An Accelerated Decrease In Autism, Christina R. Muratore, Nathaniel W. Hodgson, Malav S. Trivedi, Hamid M. Abdolmaleky, Antonio M. Persico, Carla Lintas, Suzanne De La Monte, Richard C. Deth
Age-Dependent Decrease And Alternative Splicing Of Methionine Synthase Mrna In Human Cerebral Cortex And An Accelerated Decrease In Autism, Christina R. Muratore, Nathaniel W. Hodgson, Malav S. Trivedi, Hamid M. Abdolmaleky, Antonio M. Persico, Carla Lintas, Suzanne De La Monte, Richard C. Deth
Richard Deth
The folate and vitamin B12-dependent enzyme methionine synthase (MS) is highly sensitive to cellular oxidative status, and lower MS activity increases production of the antioxidant glutathione, while simultaneously decreasing more than 200 methylation reactions, broadly affecting metabolic activity. MS mRNA levels in postmortem human cortex from subjects across the lifespan were measured and a dramatic progressive biphasic decrease of more than 400-fold from 28 weeks of gestation to 84 years was observed. Further analysis revealed alternative splicing of MS mRNA, including deletion of folate-binding domain exons and age-dependent deletion of exons from the cap domain, which protects vitamin B12 (cobalamin) …
A Comparison Of A Matrix Programming And Standard Discrete Trial Training Format To Teach Two-Component Tacts, Emily Braff
A Comparison Of A Matrix Programming And Standard Discrete Trial Training Format To Teach Two-Component Tacts, Emily Braff
USF Tampa Graduate Theses and Dissertations
Teaching using matrix programming has been shown to result in recombinative generalization. However, this procedure has not been compared to more standard discrete trial training formats such as DTT. This study compared acquisition and recombinative generalization of two-component tacts using each procedure. Matrix training was found to be more efficient than the DTT format. Half the amount of teaching was required to teach roughly the same number of targets using matrix training as compared to DTT.
The Sensory Processing Patterns And Activity Choices Of A Child With Autism Spectrum Disorder: A Mixed-Methods Case Study, Valerie Miller
The Sensory Processing Patterns And Activity Choices Of A Child With Autism Spectrum Disorder: A Mixed-Methods Case Study, Valerie Miller
Online Theses and Dissertations
It is estimated that up to 95% of children with autism spectrum disorder experience sensory processing problems. Minimal research is available on the relationship between specific sensory processing patterns, activity preference and behavior patterns in children. It is hypothesized that if children participate in play activities that support their sensory needs, they will experience less behavioral problems, more self-regulating behavior and a higher quality of life. This mixed-methods case study examines how a child with autism spectrum disorder participates in activities and looks at if those activities support sensory needs, thus reinforcing self-regulatory behaviors.
The Silhouettes Of Autism, Chloe J. Dobbert
The Silhouettes Of Autism, Chloe J. Dobbert
CMC Senior Theses
My passion as a student at the Claremont Colleges is to help children with Autism Spectrum Disorder grow and learn as normal children and to help prepare them for life outside the Autism Center at Claremont McKenna College. In my thesis project, I am exploring the concept of silhouettes through photography and my perceptions of the stories told to me by the children I teach. Esthetically, I am inspired by Kara Walker’s installation of large cutout silhouettes but I am using different mediums to accomplish my project: Artistically, I am inspired by the detailed descriptions of the obsessive stories and …