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Full-Text Articles in Medicine and Health Sciences
Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang
Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang
Electronic Thesis and Dissertation Repository
The considerable variation in the spatial distribution of cortical thickness changes has been used to parse heterogeneity in schizophrenia. We aimed to recover a ‘cortical impoverishment’ subgroup with widespread cortical thinning. We applied hierarchical cluster analysis to cortical thickness data of three datasets in different stages of psychosis and studied the cognitive, functional, neurochemical, language and symptom profiles of the observed subgroups. Our consensus-based clustering procedure consistently produced a subgroup characterized by significantly lower cortical thickness. This ‘cortical impoverishment’ subgroup was associated with a higher symptom burden in a clinically stable sample and higher glutamate levels with language impairments in …
A Life Lived With Schizophrenia: When Mother’S Love Is Kept In The Dark Exploring Maternal Communication And Attachment Organization In Families With Schizophrenia, Myrsini Stefanidou Marini
A Life Lived With Schizophrenia: When Mother’S Love Is Kept In The Dark Exploring Maternal Communication And Attachment Organization In Families With Schizophrenia, Myrsini Stefanidou Marini
Electronic Theses and Dissertations
In recent years, research into the transgenerational transmission of attachment styles has shown that a mother’sattachment style often predicts the attachment style of her infant. Fearsome parental behavior has been found to predict disorganized attachment in infants, which is further associated with a range of mental health disturbances in adolescence. Furthermore, regular patterns of disturbed communication between mother and child have also been found to lead to ‘schizophrenic’ thinking and behavior in the child’s life. While acknowledging that genetic and other biological factors contribute to the emergence of schizophrenia, this study focused on disorganized attachment and disturbed communication between mother …
A Comparison Of Stigma Levels For Individuals With Psychological Disorders And Individuals With Intellectual Disabilities, Isabella E. Wood
A Comparison Of Stigma Levels For Individuals With Psychological Disorders And Individuals With Intellectual Disabilities, Isabella E. Wood
Honors Theses
This study compared nine aspects of stigmatization (blame, anger, pity, help, dangerousness, fear, avoidance, segregation, coercion) amongst schizophrenia, binge eating, and intellectual disabilities. The overall MANOVA was significant, F(18, 183) = 89.95, p < .001, Wilks’ Lambda = .10. When the results for the dependent variables were considered separately, all nine dependent variables reached significance (p < .001). Schizophrenia scored highest in all categories except blame and pity. Blame was the highest for binge eating and pity was the highest for intellectual disabilities. Efforts to reduce stigmatization must be tailored to each disorder.
Examination Of Common And Rare Variant Genetic Architecture Of Psychiatric Disorders, Mohammad Ahangari
Examination Of Common And Rare Variant Genetic Architecture Of Psychiatric Disorders, Mohammad Ahangari
Theses and Dissertations
Psychiatric disorders are often heterogenous in their manifestation and genome-wide association studies have identified many common risk variants involved in their polygenic architectures with varying degrees of pleiotropy. In recent years, large-scale biobanks have also begun sequencing the genome of their participants to elucidate the role of rare risk variation in the genetic architecture of complex phenotypes, including psychiatric traits. This dissertation sought to better understand the role of both common and rare risk variation in the genetic architecture of psychiatric disorders with a particular focus on schizophrenia and alcohol problems. In the first three analyses, we focused on characterizing …