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Enduring Influences Of Peripubertal/Adolescent Stressors On Behavioral Response To Estradiol And Progesterone In Adult Female Mice, Julie Laroche, Lauren Gasbarro, James P. Herman, Jeffrey D. Blaustein
Enduring Influences Of Peripubertal/Adolescent Stressors On Behavioral Response To Estradiol And Progesterone In Adult Female Mice, Julie Laroche, Lauren Gasbarro, James P. Herman, Jeffrey D. Blaustein
Jeffrey D. Blaustein
Exposure to stressors during particular stages of development leads to acute and long-term physiological and behavioral changes. We have reported that shipping mice during the peripubertal/adolescent period results in decreased induction of feminine sexual behavior by estradiol and progesterone in adult female mice. To study further the factors involved in this decreased behavioral response, female mice were exposed to a variety of experimental stressors when 6 wk old. Effects of peripubertal/adolescent exposure to these stressors on acute plasma corticosterone levels and changes in body weight and adult behavioral response to estradiol and progesterone were assessed. Although restraint for three daily …
Reduced Behavioral Response To Gonadal Hormones In Mice Shipped During The Peripubertal/Adolescent Period, Julie Laroche, Lauren Gasbarro, James P. Herman, Jeffrey D. Blaustein
Reduced Behavioral Response To Gonadal Hormones In Mice Shipped During The Peripubertal/Adolescent Period, Julie Laroche, Lauren Gasbarro, James P. Herman, Jeffrey D. Blaustein
Jeffrey D. Blaustein
Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in adulthood than female mice shipped in adulthood (12 wk old). These shipping-induced reductions in female sexual behavior appear to be limited to a vulnerable period around the time of puberty. Likewise, male mice shipped at 6 wk of age express lower levels of masculine sexual behavior in response to testosterone treatment as adults than do …