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Full-Text Articles in Medicine and Health Sciences
Reliability Of Neuroanatomical Measurements In A Multisite Longitudinal Study Of Youth At Risk For Psychosis, T. D. Cannon, L. J. Seidman, H. W. Thermenos, B. A. Cornblatt, D. M. Olvet, D. Perkins, M. L. Qiu, D. H. Mathalon, P. Thompson, A. W. Toga, +19 Additional Authors
Reliability Of Neuroanatomical Measurements In A Multisite Longitudinal Study Of Youth At Risk For Psychosis, T. D. Cannon, L. J. Seidman, H. W. Thermenos, B. A. Cornblatt, D. M. Olvet, D. Perkins, M. L. Qiu, D. H. Mathalon, P. Thompson, A. W. Toga, +19 Additional Authors
Journal Articles
Multisite longitudinal neuroimaging designs are used to identify differential brain structural change associated with onset or progression of disease. The reliability of neuroanatomical measurements over time and across sites is a crucial aspect of power in such studies. Prior work has found that while within-site reliabilities of neuroanatomical measurements are excellent, between-site reliability is generally more modest. Factors that may increase between-site reliability include standardization of scanner platform and sequence parameters and correction for between-scanner variations in gradient nonlinearities. Factors that may improve both between- and within-site reliability include use of registration algorithms that account for individual differences in cortical …
Independent Component Analysis Of Resting State Activity In Pediatric Obsessive-Compulsive Disorder, P. Gruner, A. Vo, M. Argyelan, T. Ikuta, A. J. Degnan, M. John, B. D. Peters, A. K. Malhotra, A. M. Ulug, P. Szeszko
Independent Component Analysis Of Resting State Activity In Pediatric Obsessive-Compulsive Disorder, P. Gruner, A. Vo, M. Argyelan, T. Ikuta, A. J. Degnan, M. John, B. D. Peters, A. K. Malhotra, A. M. Ulug, P. Szeszko
Journal Articles
Obsessive-compulsive disorder (OCD) is an often severely disabling illness with onset generally in childhood or adolescence. Little is known, however, regarding the pattern of brain resting state activity in OCD early in the course of illness. We therefore examined differences in brain resting state activity in patients with pediatric OCD compared with healthy volunteers and their clinical correlates. Twenty-three pediatric OCD patients and 23 healthy volunteers (age range 9-17), matched for sex, age, handedness, and IQ completed a resting state functional magnetic resonance imaging exam at 3T. Patients completed the Children's Yale Brown Obsessive Scale. Data were decomposed into 36 …
Reliability Of Functional Magnetic Resonance Imaging Activation During Working Memory In A Multi-Site Study: Analysis From The North American Prodrome Longitudinal Study, J. K. Forsyth, C. E. Bearden, J. Addington, B. Goodyear, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. M. Olvet, M. L. Qiu, T. D. Cannon, +13 Additional Authors
Reliability Of Functional Magnetic Resonance Imaging Activation During Working Memory In A Multi-Site Study: Analysis From The North American Prodrome Longitudinal Study, J. K. Forsyth, C. E. Bearden, J. Addington, B. Goodyear, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. M. Olvet, M. L. Qiu, T. D. Cannon, +13 Additional Authors
Journal Articles
Multi-site neuroimaging studies offer an efficient means to study brain functioning in large samples of individuals with rare conditions; however, they present new challenges given that aggregating data across sites introduces additional variability into measures of interest. Assessing the reliability of brain activation across study sites and comparing statistical methods for pooling functional data are critical to ensuring the validity of aggregating data across sites. The current study used two samples of healthy individuals to assess the feasibility and reliability of aggregating multi-site functional magnetic resonance imaging (fMRI) data from a Sternberg-style verbal working memory task. Participants were recruited as …