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Zucker School of Medicine at Hofstra/Northwell
Brain connectivity;; basal ganglia;; psychosis;; state;; dopamine;; medication;; salience;; fmri;; abnormalities;; metaanalysis;; Psychiatry
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Full-Text Articles in Medicine and Health Sciences
Antipsychotic Treatment And Functional Connectivity Of The Striatum In First-Episode Schizophrenia, D. K. Sarpal, D. G. Robinson, T. Lencz, M. Argyelan, T. Ikuta, K. Karlsgodt, J. Gallego, J. M. Kane, P. R. Szeszko, A. K. Malhotra
Antipsychotic Treatment And Functional Connectivity Of The Striatum In First-Episode Schizophrenia, D. K. Sarpal, D. G. Robinson, T. Lencz, M. Argyelan, T. Ikuta, K. Karlsgodt, J. Gallego, J. M. Kane, P. R. Szeszko, A. K. Malhotra
Journal Articles
IMPORTANCE Previous evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although the striatum is the primary target of all efficacious antipsychotics, the relationship between its functional connectivity and symptomatic reduction remains unknown. OBJECTIVE To explore the longitudinal effect of treatment with second-generation antipsychotics on functional connectivity of the striatum during the resting state in patients experiencing a first episode of psychosis. DESIGN, SETTING, AND PARTICIPANTS This prospective controlled study took place at a clinical research center and included 24 patients with first-episode psychosis and 24 healthy participants matched for age, sex, education, and handedness. Medications were administered in …