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Full-Text Articles in Medicine and Health Sciences
Investigation Of Lung Structure-Function Relationships Using Hyperpolarized Noble Gases, Robert P. Thomen
Investigation Of Lung Structure-Function Relationships Using Hyperpolarized Noble Gases, Robert P. Thomen
Arts & Sciences Electronic Theses and Dissertations
Magnetic Resonance Imaging (MRI) is an application of the nuclear magnetic resonance (NMR) phenomenon to non-invasively generate 3D tomographic images. MRI is an emerging modality for the lung, but it suffers from low sensitivity due to inherent low tissue density and short T2*. Hyperpolarization is a process by which the nuclear contribution to NMR signal is greatly enhanced to more than 100,000 times that of samples in thermal equilibrium. The noble gases 3He and 129Xe are most often hyperpolarized by transfer of light angular momentum through the electron of a vaporized alkali metal to the noble …
Modeling The Spatiotemporal Dynamics Of Cells In The Lung, Joshua Jeremy Pothen
Modeling The Spatiotemporal Dynamics Of Cells In The Lung, Joshua Jeremy Pothen
Graduate College Dissertations and Theses
Multiple research problems related to the lung involve a need to take into account the spatiotemporal dynamics of the underlying component cells. Two such problems involve better understanding the nature of the allergic inflammatory response to explore what might cause chronic inflammatory diseases such as asthma, and determining the rules underlying stem cells used to engraft decellularized lung scaffolds in the hopes of growing new lungs for transplantation. For both problems, we model the systems computationally using agent-based modeling, a tool that enables us to capture these spatiotemporal dynamics by modeling any biological system as a collection of agents (cells) …