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Modeling Of Anticancer Drug Delivery By Temperature-Sensitive Liposomes, Vera Franziska Loeser

Theses and Dissertations

Cytotoxic anticancer drugs are used to treat cancer, particularly tumors. These drugs themselves do not distinguish between healthy and tumor cells and attack all of them. Consequently physicians and chemists investigate safer ways of delivery that minimize damage to healthy cells. One of these ways are liposomal formulations of the anticancer drugs. Liposomes are vesicles that encapsulate the drug to shield the healthy parts of the body from the toxicity of the drugs. Due to the abnormal structure of tumors, especially their leaky vasculature, these macromolecules are able to diffuse into the tumor tissue whereas the normal vasculature prevents them …