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Full-Text Articles in Medicine and Health Sciences
Development Of A Surgical Instrument Prototype To Perform A More Precise Capsulorhexis, Kirk Haugen
Development Of A Surgical Instrument Prototype To Perform A More Precise Capsulorhexis, Kirk Haugen
Journal of Interdisciplinary Undergraduate Research
Performing capsulorhexis is often considered the most difficult part of cataract surgery. Not only is it difficult, but performing it correctly is important for refractive outcomes.4 Inaccurate capsulorhexes are associated with complications including posterior capsular opacification, capsular fibrosis, and capsular phimosis.6 This study investigates the possibility of a proposed surgical instrument producing more precise capsulorhexes as determined by the circularity index. 60 capsulorhexes were performed on cigarette paper laid over clay - half using the continuous curvilinear capsulorhexis (CCC) method, and half using the proposed instrument. The precision of the capsulorhexis was then measured using the circularity index. …
Innovative Synthesis Of Diltiazem/Clentiazem Analogs, Emelyn Magtanong
Innovative Synthesis Of Diltiazem/Clentiazem Analogs, Emelyn Magtanong
Journal of Interdisciplinary Undergraduate Research
Cardiovascular disease defines disorders of the heart and blood vessels, and is the number one cause of death in America. Diltiazem and clentiazem are common calcium channel blockers incorporated into drugs used to treat various cardiovascular diseases. Methods to synthesize 5-[2-(dimethylamino)ethyl]-8-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one, an analog of the core of diltiazem and clentiazem, using cost-efficient starting materials allows for affordable treatment and increased availability to affected individuals. N-(N,N-dimethylethanamine)-4-aminophenol can be oxidized to form a quineoneimine, which can be further reacted with 3-mercaptopropionic acid via Michael addition. Subsequent addition of a coupling reagent, N,N'-dicyclocarbodiimide (DCC),1 produces 5-[2-(dimethylamino)ethyl]-8-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one, analogous to the core …
Inhibiting Fatty Acid Synthase In Rapidly Dividing Cells: Synthesis Of 5-(Alkylthio)-1h-Benzo[D]Imidazole-2,6-Diones, Andy Hausted
Inhibiting Fatty Acid Synthase In Rapidly Dividing Cells: Synthesis Of 5-(Alkylthio)-1h-Benzo[D]Imidazole-2,6-Diones, Andy Hausted
Journal of Interdisciplinary Undergraduate Research
Prostate and breast cancer are the number one and number two cancer sites, respectively, for male and females within the United States.1 Increased levels of the enzyme fatty acid synthase have been found in rapidly dividing cancer cells. This enzyme is responsible for the de novo synthesis of fatty acids in human cells, which are essential to cell growth and survival. The goal then for this research is to synthesize and design a new synthesis of 5-(alkylthio)-1Hbenzo[ d]imidazole-2,6-diones intended to successfully inhibit fatty acid synthase (FASN) by binding allosterically to the thioesterase domain of FASN. Thus by selectively inhibiting FASN …