Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Prevention Of Poxvirus Infection By Tetrapyrroles, Avril Rm Chen-Collins, Dabney W. Dixon, Andrei N. Vzorov, Luigi G. Marzilli, Richard W. Compans
Prevention Of Poxvirus Infection By Tetrapyrroles, Avril Rm Chen-Collins, Dabney W. Dixon, Andrei N. Vzorov, Luigi G. Marzilli, Richard W. Compans
Chemistry Faculty Publications
Background: Prevention of poxvirus infection is a topic of great current interest. We report inhibition of vaccinia virus in cell culture by porphyrins and phthalocyanines. Most previous work on the inhibition of viruses with tetrapyrroles has involved photodynamic mechanisms. The current study, however, investigates light-independent inhibition activity.
Methods: The Western Reserve (WR) and International Health Department-J (IHD-J) strains of vaccinia virus were used. Virucidal and antiviral activities as well as the cytotoxicity of test compounds were determined.
Results: Examples of active compounds include zinc protoporphyrin, copper hematoporphyrin, meso(2,6-dihydroxyphenyl)porphyrin, the sulfonated tetra-1-naphthyl and tetra-1- anthracenylporphyrins, selected sulfonated derivatives of halogenated tetraphenyl …