Medicine and Health Sciences Commons^™

A Mathematical Analysis Of Drug Dissolution In The Usp Flow Through Apparatus, David Mcdonnell, Deirdre M. D'Arcy, Lawrence J. Crane, Brendan Redmond

Articles

This paper applies boundary layer theory to the process of drug dissolution in the USP (United States Pharmacopeia) Flow Through Apparatus. The mass transfer rate from the vertical planar surface of a compact within the device is examined. The theoretical results obtained are then compared with those of experiment. The paper also examines the effect on the dissolution process caused by the interaction between natural and forced convection within the apparatus and the introduction of additional boundaries.

Development Of Sensitive Holographic Devices For Physiological Metal Ion Detection, Sabad-E- Gul, Suzanne Martin, John Cassidy, Izabela Naydenova

Conference Papers

The development of selective alkali metal ions sensors in particular is a subject of significant interest. In this respect, the level of blood electrolytes, particularly H+, Na+, K+ and Cl- , is widely used to monitor aberrant physiologies associated with pulmonary emphysema, acute and chronic renal failure, heart failure, diabetes. The sensors reported in this paper are created by holographic recording of surface relief structures in a self-processing photopolymer material. The structures are functionalized by ionophores dibenzo-18-crown-6 (DC) and tetraethyl 4-tert-butylcalix[4]arene (TBC) in plasticised polyvinyl chloride (PVC) matrix. Interrogation of these structures by light allows indirect measurements of chemical analytes’ …

Broadband Acoustic Measurement Of The Agar-Based Tissue Mimicking Material – A Longitudinal Study, Adela Rabell-Montiel, Jacinta Browne, Stephen Pye, Tom Anderson, Carmel Moran

Articles

Commercially available ultrasound quality assurance test phantoms rely upon the long-term acoustic stability of tissue-mimicking-materials (TMMs). The measurement of the acoustic properties can be technically challenging and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique is proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics. The acoustic properties were evaluated using a broadband pulse-echo substitution technique over the frequency range of 4.5 – 50 MHz at …

Ultra-Filtration Of Human Serum For Improved Quantitative Analysis Of Low Molecular Weight Biomarkers Using Atr-Ir Spectroscopy, Franck Bonnier, Luis Felipe Cs. Carvalho, Matthew J. Baker, Hugh Byrne, Igor Chourpa

Articles

Infrared spectroscopy is a reliable, rapid and cost effective characterisation technique, delivering a molecular finger print of the sample. It is expected that its sensitivity would enable detection of small chemical variations in biological samples associated with disease. ATR-IR is particularly suitable for liquid sample analysis and, although air drying is commonly performed before data collection, just a drop of human serum is enough for screening and early diagnosis. However, the dynamic range of constituent biochemical concentrations in the serum composition remains a limiting factor to the reliability of the technique. Using glucose as a model spike in human serum, …

Extraoral Maxillofacial Prosthesis Implant Retention Systems: A Critical Review., Hugh Byrne, Marina L. Pimentel

Articles

Objectives: The purpose of this literature review is to provide information on the different available techniques for implant-supported prosthetic retention, which are bar-clip, o-ring or magnets. Through presenting the practitioner preferences reported in literature, although limited from strict comparison due to the heterogeneity of methodologies and studied individuals, this review aims to identify the choices for maxillofacial prosthesis implant retention systems, regarding patient comfort and good aesthetic outcome, as an aid to surgical and prosthetic planning for implant-supported extraoral maxillofacial prosthetics. With proper knowledge of each implant retention system, a practitioner can design a treatment plan which allows for a …

Biofunctionalized Capillary Flow Channel Platform Integrated With 3d Nanostructured Matrix To Capture Circulating Tumor Cells, Shashwat Banerjee, Ganesh Khutale, Vrushali Khobragade, Narendra Kale, Milind Pore, Govind Chate, Archana Jalota-Badhwar, Manoj Dongare, Jayant Khandare

Articles

Circulating tumor cells (CTCs) from peripheral blood account genetic information for cancer diagnosis and overall disease monitoring. Analysis of “liquid biopsy” holds immense promise as it may lead to new approaches for cancer treatment. The study reports effective and continuous flow microchannel system for isolating CTCs using transferrin conjugated 3D matrix synthesized by crosslinking polyethylene glycol-Fe3O4 nanostructures for rapid and efficient capturing of CTCs. The platform provides option of using multiple microchannel units in series that can influence higher cell-capture efficiency due to increasing cell-substrate contact frequency. CTCs are captured with high efficiency even at low concentration of target cells …

Thermostability Of The Coating, Antigen And Immunostimulator In An Adjuvanted Oral Capsule Vaccine Formulation, Stephanie Longet, Vincenzo Aversa, Daire O'Donnell, Joshua Tobias, Monica Rosa, Jan Holmgren, Ivan Coulter, Ed Lavelle

Articles

Oral vaccines present an attractive alternative to injectable vaccines for enteric diseases due to ease of delivery and the induction of intestinal immunity at the site of infection. However, susceptibility to gastrointestinal proteolysis, limited transepithelial uptake and a lack of clinically acceptable adjuvants present significant challenges. A further challenge to mass vaccination in developing countries is the very expensive requirement to maintain the cold chain. We recently described the effectiveness of a Single Multiple Pill® (SmPill®) adjuvanted capsule approach to enhance the effectiveness of a candidate enterotoxigenic Escherichia coli (ETEC) oral vaccine. Here it was demonstrated that this delivery system …

Graphene Toxicity As A Double-Edged Sword Of Risks And Exploitable Opportunities: A Critical Analysis Of The Most Recent Trends And Developments, Yuri Volkov, Jennifer Mcintyre, Adriele Prina-Mello

Articles

Increased production volumes and a broadening application spectrum of graphene have raised concerns about its potential adverse effects on human health. Numerous reports demonstrate that graphene irrespective of its particular form exerts its effects on a widest range of living organisms, including prokaryotic bacteria and viruses, plants, micro-and macro-invertebrates, mammalian and human cells and whole animals in vivo. However, the available experimental data is frequently a matter of significant divergence and even controversy. Therefore, we provide here a critical analysis of the most recent (2015-2016) reports accumulated in the graphene-related materials biocompatibility and toxicology field in order to elucidate the …

Petrochemical Plant Console Operator Workload:The Issues, David A. Strobhar

H-Workload 2017: Models and Applications (Works in Progress)

The console operators of certain petrochemical processes must maintain high levels of performance during process upsets or endanger personnel safety and the environment. Mismanagement of an upset can result in explosions, fires, and the release of hazardous chemicals to the environment. The change in workload from steady state to upset operation is significant, with alarms and control changes that are of an order of magnitude. This paper describes the state of console activity in process plants, particularly the increase with key upsets. Quantitative data on the nature of the console operator’s position, its workload during normal operation, and the requirements …

A Workload-Centered Perspective On Reduced Crew Operations In Commercial Aviation, Daniela Schmid

H-Workload 2017: Models and Applications (Works in Progress)

Mental workload of a pilot, in short workload, depends on various characteristics of different accumulated tasks on the flight deck. Exogenous task demands and endogenous supply of attentional or information processing resources determine workload [1]. Performance is expect to drop if the demand exceeds the available resources of the pilot. Expertise and experience modulate the endogenous sup- ply of resources like perceiving, updating memory, planing, making a decision, and executing and processing a response. Subsequently, workload manifests in performance variables, subjective experience, and physiological parameters [2]. This is how we can summarize workload very brie y to introduce a model …

Moving Between Automated And Manual Driving: Mental Workload And Performance Implications, Totsapon Butmee, Terry C. Lansdown

H-Workload 2017: Models and Applications (Works in Progress)

Automated driving has been predicted to take-over from manual vehicle control in the near future. The driver’s role may then change from active operator to passive observer. Such technology offers the tantalising promise of improving driving safety. However, many studies have presented findings suggesting potentially adverse effects from automated driving systems, e.g., reduced situation awareness. Mental workload is also a key issue of concern for researchers in this area. Excessive mental workload has repeatedly been shown to be associated with degraded driving performance. Previously, most traffic psychology studies on mental workload have focused the manual driving task. However, a shift …

Online Measuring Of Available Resources, Enrique Munoz-De-Escalona, José Juan Canas

H-Workload 2017: Models and Applications (Works in Progress)

This paper present a proposal for measuring available mental resources during the accomplishment of a task. Our proposal consists in measuring emotions provoked by perceived self-efficacy in the execution of the task. Self-efficacy is one of the most important factors that affect the resources that a person puts at the disposal of the execution of the task. When a person perceives that he/she is not being effective he/she will activate more resources to improve his performance. This self-efficacy will be reflected in the emotions that the person experiences. A good efficacy will provoke positive emotions and a bad efficacy negative …

A System To Monitor Cognitive Workload In Naturalistic High-Motion Environments, Bethany K. Bracken, Seth Elkin-Frankston, Noa Palmon, Michael Farry, Blaise De B Frederick

H-Workload 2017: Models and Applications (Works in Progress)

Across many careers, individuals face alternating periods of high and low attention and cognitive workload can impair cognitive function and undermine job performance. We have designed and are developing an unobtrusive system to Monitor, Extract, and Decode Indicators of Cognitive Workload (MEDIC) in naturalistic, high-motion environments. MEDIC is designed to warn individuals, teammates, or supervisors when steps should be taken to augment cognitive readiness. We first designed and manufactured a forehead sensor device that includes a custom fNIRS sensor and a three-axis accelerometer designed to be mounted on the inside of a baseball cap or headband, or standard issue gear …

Distress And Worry As Mediators In The Relationship Between Psychosocial Risks And Upper Body Musculosketal Complaints In Highly Automated Manufacturing, Fiona Wixted, Leonard O'Sullivan

H-Workload 2017: Models and Applications (Works in Progress)

As a result of an upward trend in automation, the requirement for supervisory monitoring and consequently, cognitive demand has increased in automated manufacturing. The incidence of musculoskeletal disorders has also increased in the manufacturing sector. A model was developed based on survey data to test if distress and worry mediate the relationship between psychosocial factors (job control, cognitive demand, social isolation and skill discretion), stress states and upper body musculoskeletal complaints in highly automated manufacturing companies (n=235). Cognitive demand was shown to be related to higher distress in employees. The data raise the question about the link between job control …

Towards A Not Obtrusive Low Cost Biosystem To Assess Risk Perception In Workplace Through Stress Detection, Emanuele Bellini, Serena Benevenuti, Chiara Batistini

H-Workload 2017: Models and Applications (Works in Progress)

The main aim of the article is to build a method to assess risk perception in real time in order to early detect and prevent risk behaviors and possible human errors. To this end, the relation between mental workload and stress as critical factors affecting risk perception has been investigated. In particular the mental-physical activation generated by an increment of the workload has the effect of reducing the resources needed to perceive risk increasing the worker vulnerability. The complexity of the stress phenomenon suggested the adoption of an integrated view. The Functional Model has been adopted to for its holistic …

Reducing Peak Workload In The Cockpit: A Human In The Loop Simulation Evaluating New Runway Selection Tool, Tanja Bos, Rolf Zon, Wilfred Rouwhorst

H-Workload 2017: Models and Applications (Works in Progress)

In efforts to increase safety and reduce peak workload situations in the cockpit, a tool with a different interaction style was developed for use in case of a runway change instructed by Air Traffic Control during approach. In an experiment a workload comparison was made between the new tool and the conventional cockpit. Workload was measured by means of a self-rating after each experiment run, as well as eye blink frequency during each run. Results show that the self-rated workload decreases with the new tool for one of the two crew members and the blink frequency suggests a workload decrease …

A Pilot Study Into Bio-Behavioural Measurements On Air Traffic Controllers In Remote Tower Operations, Tanja Bos, Rolf Zon, Eszter Furedi, Dezso Dudas, Daniel Rohacs

H-Workload 2017: Models and Applications (Works in Progress)

What is the impact of shifting to remote tower operations on the Air Traffic Controller? In the joint HungaroControl-Netherlands Aerospace Centre NLR pilot project an assessment of bio-behaviour on three air traffic controllers was made in a remote tower and conventional tower. The research is motivated by HungaroControl’s plans in shifting to remote tower operations at Budapest airport in the upcoming years. This pilot project is considered a feasibility study to investigate if an eye tracker and a heart rate sensor can be used to derive workload, the controllers’ division of attention over information elements, and scanning strategies in two …

Towards A Continuous Assessment Of Cognitive Workload For Smartphone Multitasking Users, Angel Jimenez-Molina, Hernan Lira

H-Workload 2017: Models and Applications (Works in Progress)

The intermeshing of Smartphone interactions and daily activities depletes the availability of cognitive resources. This excessive demand may lead to several undesirable cognitive states, which can be avoided by continuously assessing the user cognitive workload. Recently, many attempts have emerged to assess this workload by using psycho physiological signals. This paper provides evidence that it is possible to train models that accurately identify in short time windows such cognitive workload by processing heart rate and blood oxygen saturation signals. This assessment could be applied in Smartphone notification delivery, interface adaptations or cognitive capabilities evaluation.

Retention Systems For Extraoral Maxillofacial Prosthetic Implants: A Critical Review, M.V. Cobein, N.P. Coto, O. Crivello Junior, J.B.D. Lemos, L.M. Vieira, M.L. Pimentel, Hugh Byrne, R.B. Dias

Articles

We describe the techniques available for retention of implant-supported prostheses: bar-clips, O-rings, and magnets. We present reported preferences and, although this is limited by the heterogeneity of methods used and patients studied, we hope we have identified the best retention systems for maxillofacial prosthetic implants. If practitioners know the advantages and disadvantages of each system, they can choose the most natural and comfortable prosthesis. We searched the PubMed and Scopus databases, and restricted our search to papers published 2001–13. MeSH terms used were Maxillofacial prosthesis and Craniofacial prosthesis OR Craniofacial prostheses. We found a total of 2630 papers, and after …

Quantification Of Trace Metals In Infant Formula Premixes Using Laser-Induced Breakdown Spectroscopy, Raquel Cama-Moncunill, Maria Piedad Casado-Gavalda, Xavier Cama-Moncunill, Maria Markiewicz-Keszycka, Yash Dixit, Patrick J. Cullen, Carl Sullivan

Articles

Infant formula is a human milk substitute generally based upon fortified cow milk components. In order to mimic the composition of breast milk, trace elements such as copper, iron and zinc are usually added in a single operation using a premix. The correct addition of premixes must be verified to ensure that the target levels in infant formulae are achieved. In this study, a laser-induced breakdown spectroscopy (LIBS) system was assessed as a fast validation tool for trace element premixes. LIBS is a promising emission spectroscopic technique for elemental analysis, which offers real-time analyses, little to no sample preparation and …

Evaluation Of Levels Of Antibiotic Resistance In Groundwater-Derived E. Coli Isolates In The Midwest Of Ireland And Elucidation Of Potential Predictors Of Resistance, Jean O'Dwyer, Paul Hynds, Matthieu Pot, Catherine Adley, Michael Ryan

Articles

Antibiotic-resistant (pathogenic and non-pathogenic) organisms and genes are now acknowledged as significant emerging aquatic contaminants with potentially adverse human and ecological health impacts, and thus require monitoring. This study is the first to investigate levels of resistance among Irish groundwater (private wells) samples; Escherichia coli isolates were examined against a panel of commonly prescribed human and veterinary therapeutic antibiotics, followed by determination of the causative factors of resistance. Overall, 42 confirmed E. coli isolates were recovered from a groundwater-sampling cohort. Resistance to the human panel of antibiotics was moderate; nine (21.4%) E. coli isolates demonstrated resistance to one or more …

Geospatial Drivers Of The Groundwater Δ18o Isoscape In A Temperate Maritime Climate (Republic Of Ireland), S. Regan, R. Goodhue, O. Naughton, Paul Hynds

Articles

In recent years, the concept of “isoscapes” has been used to describe spatiotemporal stable isotope distributions within natural environments including groundwater systems at multiple scales. This study presents an updated groundwater δ18O isoscape for the Republic of Ireland and describes the climatic and geological drivers influencing 18O composition. In all, 142 geographically and geologically representative groundwater installations were sampled and analysed, in addition to 35 samples from six nested boreholes. Geospatially, Irish groundwater exhibits high δ18O values in southern and western coastal regions, becoming progressively depleted inland before reaching lowest measured values along the eastern coast, equating to a national …

Bayesian Exponential Random Graph Modelling Of Interhospital Patient Referral Networks, Alberto Caimo, Francesca Pallotti, Alessandro Lomi

Articles

Using original data that we have collected on referral relations between 110 hospitals serving a large regional community, we show how recently derived Bayesian exponential random graph models may be adopted to illuminate core empirical issues in research on relational coordination among healthcare organisations. We show how a rigorous Bayesian computation approach supports a fully probabilistic analytical framework that alleviates well-known problems in the estimation of model parameters of exponential random graph models. We also show how the main structural features of interhospital patient referral networks that prior studies have described can be reproduced with accuracy by specifying the system …

A Comparison Of Stimulus Presentation Methods In Temporal Discrimination Testing, Eavan M. Mcgovern, John Butler, Ines Beiser, Laura Williams, Brendan Quinlivan, Shruti Narasiham, Rebecca Beck, Sean O'Riordan, Richard B. Reilly, Michael Hutchinson

Articles

The temporal discrimination threshold (TDT) is the shortest time interval at which an individual detects two stimuli to be asynchronous (normal  =  30-50 ms). It has been shown to be abnormal in patients with disorders affecting the basal ganglia including adult onset idiopathic focal dystonia (AOIFD). Up to 97% of patients have an abnormal TDT with age- and sex-related penetrance in unaffected relatives, demonstrating an autosomal dominant inheritance pattern. These findings support the use of the TDT as a pre-clinical biomarker for AOIFD. The usual stimulus presentation method involves the presentation of progressively asynchronous stimuli; when three sequential stimuli are …

Epidemiological, Clinical And Genetic Aspects Of Adult Onset Isolated Focal Dystonia In Ireland, L. Williams, E. Mcgovern, O. Kimmich, A. Molloy, I. Beiser, John Butler, F. Molloy, P. Logan, D.G. Healy, T. Lynch, R. Walsh, L. Cassidy, P. Moriarty, H. Moore, T. Mcswiney, C. Walsh, S. O'Riordan, M. Hutchinson

Articles

Background: Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder.

Aim: To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland.

Methods: Patients with adult onset idiopathic isolated focal dystonia were recruited from multiple sources. Diagnosis was based on assessment by a neurologist with an expertise in movement disorders. When consent was obtained, a number of clinical features including family history were assessed.

Results: On the prevalence date there were 592 individuals in Ireland …

Advancing Vibrational Spectroscopy For Cellular And Sub Cellular Analysis: Raman Spectroscopy As An In Vitro Chemotherapeutic Screeening And Assessment Protocol, Zeineb Farhane

Doctoral

Vibrational spectroscopy, including Raman micro-spectroscopy, has attracted considerable attention over the last few years, as a powerful, non-invasive tool for clinical applications, especially in cancer diagnosis, in vivo and ex vivo. As a molecular fingerprinting technique with optical resolution, Raman micro-spectroscopy is able to monitor biochemical processes, drug uptake, efficacy and mode of action and mechanisms of interaction of chemotherapeutic drugs at a subcellular level. In vitro applications may be more strategically achievable, and can help guide drug design and discovery, and eventually evaluate To this end, different lung cell lines were used and Raman micro-spectroscopy was coupled to valuable …

The Benefits Of Task And Cognitive Workload Support For Operators In Ground Handling, Maria Chiara Leva, Yilmar Builes

Conference papers

The scope of the present work is to report an action research project applied to the relationship of task and cognitive workload support on one of the most important aspects of an airport: ground handling. At the beginning of the project workload management was not in the scope of work but as the project progressed and preliminary results and feedback were gained the researcher came to realize that some form of workload management support was also achieved as a by-product. The present paper is an attempt to account for what was achieved and how. Safe and efficient ground handling during …

Human Performance Modelling In Manufacturing: Mental Workload And Task Complexity, Maria Chiara Leva, Lorenzo Comberti, Micaela Demichela, Rebecca Duane

H-Workload 2017: Models and Applications (Works in Progress)

No abstract provided.

Managing Operator Mental Workload With Standards Based Decision Support, Maurice Wilkins

H-Workload 2017: Models and Applications (Works in Progress)

H-Workload 2017: The first international symposium on human mental workload, Dublin Institute of Technology, Dublin, Ireland, June 28-30.

Facing Human Workload: The Resilient Ego: A Psychoanalytic Point Of View, Glauco Maria Genga, Maria Gabriella Pediconii

H-Workload 2017: Models and Applications (Works in Progress)

The paper aims to show new connections among Human Factors, Human Workload and Resilience. We intend: 1) to highlight the role of subject in facing the human workload, inflected as demanding tasks and emergency situations; 2) to show how psychoanalysis can provide novel insights, not only into human errors, but also into human resilience. They have a common denominator, at least in part: the role of subjective contributions even in demanding situations. Human workload includes a work for satisfaction. We recall also the case study of US Airways Flight 1549 water landing (the so called “Miracle on the Hudson”), which …