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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
In Vitro Evaluation Of Ovarian Cancer Tumorigenesis As A Function Of Quinone Oxidoreducatse-1 And Cell Phenotype, Milcah S. Jackson
In Vitro Evaluation Of Ovarian Cancer Tumorigenesis As A Function Of Quinone Oxidoreducatse-1 And Cell Phenotype, Milcah S. Jackson
LSU Doctoral Dissertations
In vitro multicellular spheroids are attractive model systems for assessing genetic and epigenetic changes that occur in diseased tissues. Understanding how such alterations in gene and subsequent protein expression affect disease progression and metastasis, drug resistance, and recurrence is of great interest in cancer research. In this regard, examining expression and activity of proteins, such as those with cytoprotective ability that are overexpressed in cancer cells, in addition to cell phenotype (i.e., stem-like, epithelial, mesenchymal, or mixed), are two ways to evaluate genetic and epigenetic changes. Moreover, determining the impact that cytoprotective proteins and cell phenotype have on tumor formation …
Stray Radiation Dose From X-Ray And Proton Beam Radiation Therapies, Christopher William Schneider
Stray Radiation Dose From X-Ray And Proton Beam Radiation Therapies, Christopher William Schneider
LSU Doctoral Dissertations
The growing population of cancer survivors at risk of radiation induced side-effects is a public health concern. These side-effects include serious conditions such as second cancers, the majority of which occur outside of the primary treatment volume. Radiotherapy treatment planning systems systematically underestimate the dose to tissues out-of-field. Attempts to predict and reduce the risks of radiogenic side effects require accurate and personalized knowledge of the out-of-field radiation dose to patients. The long-term goal of this research is to provide clinical and research tools necessary to reduce the risk of radiotherapy side effects and improve the health outcomes of radiotherapy …
Determination Of Scatter Fractions, Albedos, And Tenth Value Layers For Shielding Of Synchrotron Beamline Hutches, Bethany Lynn Broekhoven
Determination Of Scatter Fractions, Albedos, And Tenth Value Layers For Shielding Of Synchrotron Beamline Hutches, Bethany Lynn Broekhoven
LSU Master's Theses
Synchrotron facilities require substantial amounts of shielding to protect facility staff and researchers. To meet mandatory exposure limits, the traditional combination of time, distance, and shielding of the radiation source are utilized. Because of continuous 24-7 operation of most synchrotrons, time is the least useful tool. The experimental stations for synchrotron x-ray beamlines, called hutches, enforce a minimum distance from the source, but shielding provided by hutch walls is still the principal tool for a synchrotron facility. Currently there is no single resource for synchrotron beamline hutch shielding design in the literature; most hutch shielding is designed through either over-simplified …
Framework For Algorithmically Optimizing Longitudinal Health Outcomes: Examples In Cancer Radiotherapy And Occupational Radiation Protection, Lydia Joyce Wilson
Framework For Algorithmically Optimizing Longitudinal Health Outcomes: Examples In Cancer Radiotherapy And Occupational Radiation Protection, Lydia Joyce Wilson
LSU Doctoral Dissertations
Background: Advancements in the treatment of non-infectious disease have enabled survival rates to steadily increase in recent decades (e.g., diabetes, heart disease, and cancer). Epidemiological studies have revealed that the treatments for these diseases can have life-threatening and/or life–altering effects. Thus, realizing the full beneficial potential of advanced treatments necessitates new tools to algorithmically consider all major components of the health outcome, including benefit and detriment. The goal of this dissertation was to develop a framework for improving projected health outcomes following planned radiation exposures in consideration of all beneficial and detrimental, early and late, and fatal and non-fatal …
Evaluation Of Ventilation Assistance For Improving Respiratory Reproducibility In Radiation Therapy, Cameron J. Sprowls
Evaluation Of Ventilation Assistance For Improving Respiratory Reproducibility In Radiation Therapy, Cameron J. Sprowls
LSU Master's Theses
Background: Respiratory motion affects all tumor sites in the thorax and abdomen. Variations of the respiratory pattern cause variations of the tumor motion which can result in differences between the planned and delivered dose distributions. Previous breathing guidance techniques have been investigated to improve respiratory reproducibility; however, ventilation assistance has not been investigated. We evaluated using bi-level positive airway pressure (BIPAP) ventilation assistance for improving respiratory reproducibility in patients with tumor sites impacted by respiratory motion.
Methods: Written informed consent was obtained for 10 patients currently undergoing radiation therapy treatment. Patients participated in sessions over their course of treatment, which …