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Carrier-Free Chemo-Ptt/Pdt Ionic Nanomaterials For Combination Cancer Therapy, Samantha Macchi
Carrier-Free Chemo-Ptt/Pdt Ionic Nanomaterials For Combination Cancer Therapy, Samantha Macchi
Arkansas Women in STEM Conference
Herein, we describe a carrier-free combination nanodrug for treatment of cancer. In this work, we combined a photothermal compound and a chemotherapeutic drug using ionic liquid chemistry. We utilized a facile, one-step metathesis approach to replace the counter cation of a near infra-red (NIR) dye (photothermal agent) with a chemotherapeutic cation to synthesize an ionic material-based combination cancer therapy drug to deliver multiple mechanisms simultaneously. The nanodrugs were developed by using a reprecipitation method. The detailed photophysical properties of this new combination therapy molecule was investigated in ethanol solution as well as in nanoparticles forms in aqueous media. The singlet …