Medicine and Health Sciences Commons^™

The Use Of Urine Proteomic And Metabonomic Patterns For The Diagnosis Of Interstitial Cystitis And Bacterial Cystitis, Que N. Van, John R. Klose, David A. Lucas, Darue A. Prieto, Brian Luke, Jack Collins, Stanley K. Burt, Gwendolyn N. Chmurny, Haleem J. Issaq, Thomas P. Conrads, Timothy D. Veenstra, Susan K. Keay

Pharmaceutical Sciences Faculty Publications

The advent of systems biology approaches that have stemmed from the sequencing of the human genome has led to the search for new methods to diagnose diseases. While much effort has been focused on the identification of disease-specific biomarkers, recent efforts are underway toward the use of proteomic and metabonomic patterns to indicate disease. We have developed and contrasted the use of both proteomic and metabonomic patterns in urine for the detection of interstitial cystitis (IC). The methodology relies on advanced bioinformatics to scrutinize information contained within mass spectrometry (MS) and high-resolution proton nuclear magnetic resonance (1H-NMR) spectral patterns to …