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Full-Text Articles in Medicine and Health Sciences
Evaluation Of Anthelmintic Properties And Toxicity Of Pure Compounds Isolated From Dalea Spp (Plantae, Fabaceae), Victoria Lh Mcpherson
Evaluation Of Anthelmintic Properties And Toxicity Of Pure Compounds Isolated From Dalea Spp (Plantae, Fabaceae), Victoria Lh Mcpherson
All Master's Theses
Infecting upwards of a billion people worldwide, hookworm is one of the most prevalent parasitic infections affecting the world today. Those infected experience hookworm disease, characterized by severe anemia, which can lead to malnutrition, low birth weights, and physical and mental impairments. Currently, the benzimidazoles albendazole and mebendazole are used as the primary treatment; however, resistance to these drugs is emerging. Due to this resistance, finding new anthelmintic compounds active against hookworm is a priority. Previously, a pure compound isolated from Dalea ornata was identified as having strong anthelmintic activity when used against the hookworm Ancylostoma ceylanicum. This project …
Determining The Role Played By Aryl Hydrocarbon Receptor (Ahr) In The Colon Carcinoma Tumor Model, Poonam Yakkundi
Determining The Role Played By Aryl Hydrocarbon Receptor (Ahr) In The Colon Carcinoma Tumor Model, Poonam Yakkundi
University of the Pacific Theses and Dissertations
Aryl hydrocarbon receptor (AHR), commonly known as an environmental sensor involved in the metabolism and elimination of xenobiotic substances, is also an important modulator in the development and functioning of the immune system. AHR expression is varied in the T cell subsets with the highest expression in T-helper 17 and T regulatory cells. Work from many researchers has suggested that AHR can act as a tumor promoter or a tumor suppressor depending on the tumor type. Our goal is to understand the role played by AHR in MC38 syngeneic colon carcinoma tumor model. In the absence of AHR, MC38 tumor …