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Full-Text Articles in Medicine and Health Sciences
Ancestral Dependence On Breast Stemness And Nucleotide Excision Repair In Breast Cancer Stem Cells In Novel Human Model Systems, Omar Ibrahim
Student Theses, Dissertations and Capstones
Precocious puberty, measured by thelarche or menarche, is a well-established breast cancer risk factor. Using a unique and patented tissue engineering system we established cell lines from 48 primary cultures of normal breast tissue from reduction mammoplasties and used them as an in vitro model of thelarche, quantifying episphere formation and ductal differentiation. Differential ductal formation was observed based on ancestry. In light of African American (AA) precocious thelarche both in vivo and as we observed in vitro, we hypothesized that AA women would exhibit an increased proportion of breast stem cells, with greater potency for differentiation. Five AA cell …
Analysis Of Molecular Changes In 2 Types Of Non-Tumor Adjacent Breast Identified By Nucleotide Excision Repair In Early Stage Breast Cancer, Manasi Ramesh Pimpley
Analysis Of Molecular Changes In 2 Types Of Non-Tumor Adjacent Breast Identified By Nucleotide Excision Repair In Early Stage Breast Cancer, Manasi Ramesh Pimpley
Student Theses, Dissertations and Capstones
NER plays an important role in remediating DNA damage. Latimer et al., have previously shown nucleotideexcision repair (NER) to be intrinsically deficient in stage I sporadic BC by function and gene expression. Previous work performed on 12 isogenically matched stage I tumors and non-tumor adjacent (NTA) samples identified 2 types of NTA tissue with regard to functional NER. One type that represented 75% ofthe samples, had lower NER capacity, similar to the tumor (Low: Low pair). The other type had high NER relative to the tumor (High: Low pair). Two isogenic NTA/tumor cell line pairs representing these 2 types ofNTA …