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Articles 1 - 21 of 21
Full-Text Articles in Medicine and Health Sciences
Research News. Publications, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Research News. Publications, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period July 1 through December 31, 2016
Research News. Grants, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Research News. Grants, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during July-December 2016
Research News. Publications, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Research News. Publications, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period January 1, 2016 through June 30, 2016
Research News. Grants, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Research News. Grants, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during January-June 2016
Measuring And Understanding Health-Related Quality Of Life Among Adult Patients With Hemophilia, Ruchit Mukesh Shah
Measuring And Understanding Health-Related Quality Of Life Among Adult Patients With Hemophilia, Ruchit Mukesh Shah
Electronic Theses and Dissertations
Objectives: The objectives of this study are to: 1) examine the psychometric properties of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2); 2) assess the measurement invariance of the SF-12v2 with respect to age, disease severity, and treatment regimen; 3) identify psychosocial predictors of health-related quality (HRQOL) among adults with hemophilia in the United States. Methods: This cross-sectional study was conducted using both a web-based and paper-based self-administered survey. Adults with hemophilia were recruited using an online panel, a Facebook community of hemophilia patients, and at the University of Mississippi Medical Center hemophilia treatment clinic. Psychometric properties of the …
Variability In Antibacterial Chemical Defenses In Caribbean Sponges Of The Genus Aplysina, Savannah Stockton
Variability In Antibacterial Chemical Defenses In Caribbean Sponges Of The Genus Aplysina, Savannah Stockton
Honors Theses
Coral reefs represent one of the most diverse ecosystems on earth, providing habitat for at least 25% of all marine species. Coral ecosystems are faced with many stressors, both physical and biological, that are causing their continuing decline. Understanding the impacts of these stressors, and the resilience of coral reefs, is important to the long-term survival of these critical ecosystems. As a major constituent of marine communities, sponges are an important phylum contributing to the ecology of coral reefs. Like other components of coral reef habitats, sponges also face a wide variety of biological stressors including pathogens, predators, and competitors. …
Identification Of Inhibitors Of Fxii, Alexandra C. Bensel
Identification Of Inhibitors Of Fxii, Alexandra C. Bensel
Honors Theses
Hereditary angioedema is characterized by recurrent swelling of the extremities, larynx, and gastrointestinal tract. While type I and type II hereditary angioedema result from a C1-inhibitor deficiency, a new variant of the disease, type III hereditary angioedema, was recently discovered in individuals with functioning levels of the C1-inhibitor. Ongoing research has postulated that increased activity of factor XII is responsible for this new form of hereditary angioedema because it causes overproduction of bradykinin. The purpose of the experiment was to identify inhibitors of factor XII. One hundred and seventy six molecules were screened through a dose response using Human Factor …
Evaluation Of The Prevalence And Treatment Trends Of Diabetic Peripheral Neuropathy Among Patients With Diabetes In A Rural Population, Lauren Daigle
Evaluation Of The Prevalence And Treatment Trends Of Diabetic Peripheral Neuropathy Among Patients With Diabetes In A Rural Population, Lauren Daigle
Honors Theses
Evidence for adherence to the American Diabetes Association's (ADA) screening and treatment guidelines for various health complications of diabetes in rural populations is limited. The ADA recommends annual foot and eye exams and supports the use of the Semmes-Weinstein monofilament (SWM) to detect signs of diabetic peripheral neuropathy (DPN). This study evaluated the prevalence and treatment trends of DPN among patients with diabetes in a rural population. Fifty-two individuals over the age of 18, with known Type 1 or Type 2 diabetes mellitus, were recruited to participate. Participants were asked to respond to a 29-item, multiple choice and freeform question …
Patient Experiences With Small-Scale Pharmacy Compounding, Morgan Cawthon
Patient Experiences With Small-Scale Pharmacy Compounding, Morgan Cawthon
Honors Theses
Investigators examined patients' use, knowledge and perceptions of pharmacy compounding at an independent compounding pharmacy in Mandeville, Louisiana. Data were collected using a self-administered survey that patients could complete in hard-copy in the pharmacy or at home, or online using Qualtrics. Investigators found that, in some instances, patients who use compounded medications, or have a member of their household who uses compounded medications, may be more knowledgeable or have more positive perceptions of compounded medications. However, patients who did not have experience with compounds were not unknowledgeable about the practice and did not report any negative perceptions of compounding. These …
Exploring New Chemical Entities From Traditional Medicine: Docking, Synthesis And Specific Bioactivities, Chinni Yalamanchili
Exploring New Chemical Entities From Traditional Medicine: Docking, Synthesis And Specific Bioactivities, Chinni Yalamanchili
Electronic Theses and Dissertations
Traditional medical systems contributed significantly to medicine with a number of their phytochemicals found to possess good biological properties. Recently, Dr. Youyou Tu was awarded the Nobel Prize (2015) for her discovery/isolation of Artemisinin from the TCM plant Artemisia annua. Our first aim is to identify active phytochemicals against botulinum neurotoxin A (BoNT/A), and diabetes from Ayurveda and TCM, respectively, by using in silico, in vitro and in vivo approaches. In our second aim, we wanted to enantioselectively synthesize scalable quantities of phytoestrogenic isoflavans such as equol and sativan. The following three chapters summarize results of the three research goals. …
Critical Quality Attributes Of Topical Semi-Solid Dosage Forms: Solvent Activity, Muralikrishnan Angamuthu
Critical Quality Attributes Of Topical Semi-Solid Dosage Forms: Solvent Activity, Muralikrishnan Angamuthu
Electronic Theses and Dissertations
Critical quality attribute has been defined as “a physical, chemical, biological or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality”. Deviations from preset quality metrics may potentially result in drug products with inferior therapeutic efficacy and unacceptable clinical safety profile. Topical cream formulations may possess numerous quality attributes that can affect the permeation of the drug through skin and consequently therapeutic efficacy. CQAs of topical formulations are often aimed at characterizing either the physicochemical properties of APIs or bulk characteristics of the formulation itself. Solvent systems constitute a …
Novel Approaches For Ungual And Trans-Ungual Delivery Of Drugs, Avadhesh Singh Kushwaha
Novel Approaches For Ungual And Trans-Ungual Delivery Of Drugs, Avadhesh Singh Kushwaha
Electronic Theses and Dissertations
Topical therapy is commonly used for the treatment of nail diseases such as onychomycosis and nail psoriasis due to less severe side effects, non-invasiveness, direct drug delivery at the site of infection, patient compliance and lower cost of treatment. However, topical treatment is limited due to poor permeability and hard nature of nail plate. The main objective of first project was to investigate the penetrability of apremilast into and across the nail plate, folloby the preparation of a novel nail lacquer formulation to improve its ungual and trans-ungual permeation for the treatment of nail psoriasis. Dexpanthenol and salicylic acid were …
Biological And Chemical Investigation Of Panamanian Plants For Potential Utility Against Metabolic Syndrome, Yelkaira Vasquez
Biological And Chemical Investigation Of Panamanian Plants For Potential Utility Against Metabolic Syndrome, Yelkaira Vasquez
Electronic Theses and Dissertations
Metabolic syndrome (MetS) affects approximately 25% of the adult population of the world and represents a public health concern with high socioeconomic impact worldwide. Latin American populations exhibit a high prevalence of MetS, similar or even higher than developed countries. This complex and progressive disorder can develop over many years as a cluster of conditions characterized by a constellation of metabolic abnormalities. Specific guidelines have not yet been established for the treatment of MetS per se. The increased prevalence of MetS has been associated with a greater risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In …
Exploration In The Effectiveness Of Solid Lipid Nanoparticle Formulations In Enhancing Ocular Delivery Of Win 55, 212 In The Management Of Glaucoma, Emily Ann Nesbit
Exploration In The Effectiveness Of Solid Lipid Nanoparticle Formulations In Enhancing Ocular Delivery Of Win 55, 212 In The Management Of Glaucoma, Emily Ann Nesbit
Honors Theses
Glaucoma is a progressive and degenerative ocular disease which, without proper treatment, can result in permanent blindness. Due to a complex organization of lipophilic and hydrophilic ocular membranes, topical delivery of therapeutic agents has also proved to be a challenging task. Cannabinoids, such as Δ9-Tetrahydrocannabinol (THC), have intraocular pressure (IOP) lowering and neuroprotective capabilities. Due to the unfavorable physiochemical characteristics of these molecules, delivery into the eye through a topical route is very difficult. Previous research has shown that prodrug derivatization and formulations such as solid lipid nanoparticles (SLNs) improve the physiochemical characteristics and ocular bioavailability of such molecules. WIN …
Redox-Sensitive Block Copolymer Nanoparticle Preparation And Characterization, Mary Virginia Portera
Redox-Sensitive Block Copolymer Nanoparticle Preparation And Characterization, Mary Virginia Portera
Honors Theses
The purpose of the research conducted in this project was to add to a wealth of knowledge concerning chemotherapy. Although chemotherapy has been used since Paul Ehrlich's discover of Salvarsan's ability to kill Treponema pallidum (the bacterium that causes syphilis), today the term chemotherapy is mostly used in conjunction with cancer treatment. There have been many successful chemotherapy drugs produced throughout the years, but a constant problem with chemotherapy is the fact that it also affects noncancerous cells. The topic of this research investigated targeted drug delivery systems that incorporate paclitaxel, a hydrophobic chemotherapy drug. This research mainly focused on …
Students' And Pharmacists' Perspectives On The Issue Of Adhd Prescription Medication Abuse At The University Of Mississippi, Meghan Wagner
Students' And Pharmacists' Perspectives On The Issue Of Adhd Prescription Medication Abuse At The University Of Mississippi, Meghan Wagner
Honors Theses
No abstract provided.
Terpenes And Flavonoids From Salvia Apiana And Their Affinities To Cannabinoid And Opioid Receptors, Taylor Hayes
Terpenes And Flavonoids From Salvia Apiana And Their Affinities To Cannabinoid And Opioid Receptors, Taylor Hayes
Honors Theses
Salvia apiana (white sage, Lamiacae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections, and poison oak rashes. Native Americans widely used this plant in traditional Chumash healing. Infusion of the leaves is used as a diaphoretic and diuretic. The aqueous ethanolic extract of S. apiana showed moderate activity towards the CB1 receptor (58.3% displacement). The extract was fractionated on …
Saffron Extract And Its Active Constituents As Preventative And/Or Treatment Agents For Prostate Cancer Using In Vitro And In Vivo Models, Faisal Fayih Albaqami
Saffron Extract And Its Active Constituents As Preventative And/Or Treatment Agents For Prostate Cancer Using In Vitro And In Vivo Models, Faisal Fayih Albaqami
Electronic Theses and Dissertations
Saffron extract and its active constituents were evaluated as chemopreventatives and/or treatments for prostate cancer. Different models of prostate cancer (in vitro and in vivo) were used for studying saffron and its constituents’ mechanisms. In normal prostate cells, saffron extract, crocetin, and safranal, in non-toxic concentrations, possessed antioxidant properties against the reactive oxygen species induced by H2O2 which further supports saffron constituents as chemopreventative agents. Moreover, saffron and its active constituents produced cytotoxicity in prostate cancer cells through intrinsic apoptosis pathways. Potential efficacy in minimizing prostate cancer metastasis was also examined. Saffron extract, crocetin, and safranal decreased the migration and …
Evaluation And Enhancement Of Physical Stability Of Amorphous Solid Dispersions, Xin Feng
Evaluation And Enhancement Of Physical Stability Of Amorphous Solid Dispersions, Xin Feng
Electronic Theses and Dissertations
A major concern during formulation development has been to enhance the dissolution rate and bioavailability of poorly water-soluble drugs.[1],[2] The amorphous forms of APIs have attracted considerable attention as the amorphous forms tend to exhibit significantly higher levels of supersaturation in aqueous media when compared to the crystalline forms.[3],[4] For drugs which bioavailability is limited by aqueous solubility (biopharmaceutical classification system (BCS) class II drugs), which is a significant number of recently discovered drug candidates, the improved solubility may lead to enhanced bioavailability.[5-7] Oral absorption of APIs depends on two broad, but crucial, events, namely drug solubilization and gastrointestinal permeation.[8] …
Targeting Protein Kinases To Manage Or Prevent Alzheimer’S Disease, Manal A. Nael
Targeting Protein Kinases To Manage Or Prevent Alzheimer’S Disease, Manal A. Nael
Electronic Theses and Dissertations
Due to the pressing need for new disease-modifying drugs for Alzheimer’s disease (AD), new treatment strategies and alternative drug targets are currently being heavily researched. One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta (Aβ) levels is also possible through development of protein kinase C-epsilon (PKC-ϵ) activators to recover α-secretase levels and decrease toxic Aβ levels, thereby restoring synaptogenesis and cognitive function. In this way, we aim to develop …
Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil
Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil
Electronic Theses and Dissertations
Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Varying the process parameters enabled the production of SLN below 200 nm. At the end of a 5-h in-vitro dissolution study, …