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- 4-(4-methoxybenzylidene)-2-methyloxazol-5-one (1)
- 4-methoxyben- zaldehyde (1)
- Acalypha indica Linn. (1)
- Acetylglycine (1)
- Acid zirconyl-SPADNS (1)
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- Antidiabetes (1)
- Azadirachta indica A.Juss (1)
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- Curcuma domestica Val. (1)
- DNA adducts (1)
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- Extract of jackfruit cortex(Artocarpus heterophyllus) (1)
- Famotidine (1)
- Fast disintegrating tablet (1)
- Floating tablet (1)
- Fluoride ion (1)
- Gas Chromatography- Mass Spectrophotometry (1)
- Gliclazide (1)
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- Ground water (1)
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- Hyperuricemia (1)
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Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
Pengaruh Pemberian Kombinasi Ekstrak Air Akar Kucing (Acalypha Indica Linn.) Dengan Ekstrak Etanol 70% Rimpang Jahe Merah (Zingiber Officinale Rosc.) Terhadap Penurunan Kadar Asam Urat Tikus Putih, Anita Ayu Dwi Ajie Saputri, Juheini Amin, Azizahwati Azizahwati
Pengaruh Pemberian Kombinasi Ekstrak Air Akar Kucing (Acalypha Indica Linn.) Dengan Ekstrak Etanol 70% Rimpang Jahe Merah (Zingiber Officinale Rosc.) Terhadap Penurunan Kadar Asam Urat Tikus Putih, Anita Ayu Dwi Ajie Saputri, Juheini Amin, Azizahwati Azizahwati
Majalah Ilmu Kefarmasian
Hyperuricemia treatment can be given roots of Acalypha indica Linn. Combined with red ginger plant (Zingiber officinale Rosc.) as anti-inflammatory drug. This study aimed to examine the effect of aqueous extract the roots of Acalypha indica Linn. with 70%ethanol extract of rhizome of Red Ginger from the decrease in blood uric acid levels of male rats made hiperurisemia by potassium oxonate. There were 35 male white rats of Sprague Dawley strain weighing 180 g to 200 gs were divided into seven groups. Three groups were given a combination of extract, consist of a fixed dose 5.4 g/200 g bb of …
Optimasi Kecepatan Disintegrasi Tablet Terdisintegrasi Cepat (Fast Disintegrating Tablet) Domperidon Dengan Superdisintegran Sodium Starch Glycolate, Imam Prabowo, Iskandarsyah Iskandarsyah
Optimasi Kecepatan Disintegrasi Tablet Terdisintegrasi Cepat (Fast Disintegrating Tablet) Domperidon Dengan Superdisintegran Sodium Starch Glycolate, Imam Prabowo, Iskandarsyah Iskandarsyah
Majalah Ilmu Kefarmasian
Fast disintegrating tablet is one of advanced pharmaceutical technologies. Fast disintegrating tablets is a tablet when placed on the tongue will be instantly disintegrated and releases the drug with the help of saliva. This technology can solve the problem of using oral drug in patients such as pediatrics, geriatrics or in circumstances where the patient can not swallow tablets conventionally with the help of water. The purpose of this study was to optimize the speed of disintegration in fast disintegrating tablet formulations both with varying concentrations of sodium starch glycolate. Optimization the speed of disintegration was done by using sodium …
Percobaan Sintesis 4-(4-Metoksibenzilidena) 2-Metiloksazol-5-On Dari Asetilglisin Dan 4-Metoksibenzaldehid, Arif Arrahman, Hayun Hayun, Arry Yanuar
Percobaan Sintesis 4-(4-Metoksibenzilidena) 2-Metiloksazol-5-On Dari Asetilglisin Dan 4-Metoksibenzaldehid, Arif Arrahman, Hayun Hayun, Arry Yanuar
Majalah Ilmu Kefarmasian
Compound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was one of oxazolone moety derivative. Oxazolones had several different pharmacological activity depend on substituent which was bonded to oxazolone ring. Oxazolones was an important precursor for synthesizing several compounds which had pharmacological activity. For that reason, experiment to synthesize 4-(4-methoxybenzylidene)-2-methyloxazole-5-one from acetyl- glicine and 4-methoxybenzaldehyde as an oxazolone derivative become necessary. Com- pound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was synthesized over two step of reaction. First step was reacted glycine with acetic anhydride in acidic environment yielded acetylglycine. Second step was reacted acetylglycine with 4-methoxybenzaldehyde yielded 4-(4-methoxybenzylidene)-2-methyloxazole-5-one. The product, which was collected in every step, was purified by washing and recrystalization …
Efek Nefroprotektif Infus Daun Sukun (Artocarpus Altilis (Park.) Fsb.) Pada Tikus Jantan Yang Diinduksi Karbon Tetraklorida, Rianti Adi Cahyaningsih, Azizahwati Azizahwati, Dadang Kusmana
Efek Nefroprotektif Infus Daun Sukun (Artocarpus Altilis (Park.) Fsb.) Pada Tikus Jantan Yang Diinduksi Karbon Tetraklorida, Rianti Adi Cahyaningsih, Azizahwati Azizahwati, Dadang Kusmana
Majalah Ilmu Kefarmasian
Renal dysfunction can be caused by several factors, including hypertension, urinary tract obstruction, autoimmune disorders, urinary tract infection, diabetes mellitus, consumption of drugs that affect nephrotoxic and antibiotic from aminoglycoside class. Breadfruit leaves (Artocarpus altilis (Park.) Fsb.) is a traditional plant that hasbeen used empirically to treat kidney diseases. The research has been done to figure out the nephroprotective effect of breadfruit leaves infusion on white male rats strain Sprague-Dawley previously induced by carbon tetrachloride. There were 25 rats which were divided randomly into five groups. Group I which was the normal control group received CMC 0,5%. Group II which …
Uji Penghambatan Tirosinase Dan Stabilitas Fisik Sediaan Krim Pemutih Yang Mengandung Ekstrak Kulit Batang Nangka (Artocarpus Heterophyllus), Ninin Kartika Juwita, Joshita Djajadisastra, Azizahwati Azizahwati
Uji Penghambatan Tirosinase Dan Stabilitas Fisik Sediaan Krim Pemutih Yang Mengandung Ekstrak Kulit Batang Nangka (Artocarpus Heterophyllus), Ninin Kartika Juwita, Joshita Djajadisastra, Azizahwati Azizahwati
Majalah Ilmu Kefarmasian
The cortex of jackfruit (Artocarpus heterophyllus) contains some flavonoids which have activity as tyrosinase inhibitors. This compound can inhibit the oxidation of l-tyrosine and levodopa in the mechanism of melanogenesis. The extract of jackfruit cortex formulated into creams differentiated by the extract concentration of 1,5% and 2,0%. Physical stability test was conducted with storing the creams at three different temperatures, 7 ± 2°, 27 ± 2°, and 40±2°C respectively. Centrifugal tests and cycling test was also performed on both cream. Tyrosinase inhibitory activity measurement was done by in vitro studies with measuring dopachrome. The result showed that both of formulations …
Formulasi Sediaan Granul Mukoadhesif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta Indica A. Juss) Dan Kunyit (Curcuma Domestica Val.), Sutriyo Sutriyo, Khairunnisya Khairunnisya, Abdul Mun’Im
Formulasi Sediaan Granul Mukoadhesif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta Indica A. Juss) Dan Kunyit (Curcuma Domestica Val.), Sutriyo Sutriyo, Khairunnisya Khairunnisya, Abdul Mun’Im
Majalah Ilmu Kefarmasian
Neem bark (Azadirachta indica A.Juss) and turmeric (Curcuma domestica Val.) extracts have been found posses gastroprotective effect so that they are used in the treatment of gastric ulcer. Administration of combination of both extracts can give synergistic effect so that the administration dose can be reduced. In this research, combination of neem bark and turmeric extracts were formulated as mucoadhesive granules to improve their effectivenesses by increasing the residence time of dosage form in the stomach. Mucoadhesive granules were prepared by wet granulation method in six formulas using HPMC, Carbopol, and combination of HPMC and Carbopol as mucoadhesive polymers. Granules …
Analisis Kandungan Ion Fluorida Pada Sampel Air Tanah Dan Air Pam Secara Spektrofotometri, Yodifta Astriningrum, Herman Suryadi
Analisis Kandungan Ion Fluorida Pada Sampel Air Tanah Dan Air Pam Secara Spektrofotometri, Yodifta Astriningrum, Herman Suryadi
Majalah Ilmu Kefarmasian
Fluoride ion is one of the compounds that are known to have benefits in the prevention of dental caries when used in certain concentrations, but also hasnegative effects that may cause the occurrence of dental and bone fluorosis when the intake was in excessive concentration. One of the fluoride intakes comes fromwater that is consumed. The aim of this research was to identify and measurefluoride ion levels in groundwater and piped water that used as drinking water consumption in the community. Measurement of fluoride ion concentration isdone by using visible spectrophotometry at the maximum wavelength of 586 nm using the …
Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks, Erny Sagita, Effionora Anwar, Silvia Surini
Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks, Erny Sagita, Effionora Anwar, Silvia Surini
Majalah Ilmu Kefarmasian
Floating tablet is one of the drug delivery system retained in the stomach which aims to prolong the lag time of the drug in the stomach. This principle can be used to improve the efficacy of famotidine in treating diseases in the stomach The purpose of this research is to develop dosage form afloat by using Chitosan Pectin Electrolytes (PEC) as matrix then used as the matrix in tablet dosage form with famotidine as a drug model. PEC also combined with hydroxypropylmethylcellulose (HPMC) with different. PEC was also combined with hydroxypropilmethylcellulose (HPMC) in different concentrations. The results of the dissolution …
Pengembangan Sistem Penghantaran Obat Solid Self-Emulsifying Mikropartikel Gliklazid Untuk Meningkatkan Disolusi, Mega Suryani, Sutriyo Sutriyo
Pengembangan Sistem Penghantaran Obat Solid Self-Emulsifying Mikropartikel Gliklazid Untuk Meningkatkan Disolusi, Mega Suryani, Sutriyo Sutriyo
Majalah Ilmu Kefarmasian
Gliclazide is a Hypoglycemicdrug, second-generation sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Gliclazide exhibit poor aqueous solubility, so that their low bioavailability. Objectivesthis study is to develop solid self-emulsifying (SE) microparticles of poorly soluble gliclazide to dissolution enchancement. These microparticles were prepared by spray drying method, using three surfactant (acripol, tween 80 and sodium lauryl sulphate) with various concentration. SE microparticles characterized in terms of morphology (SEM), particle size distribution (PSA), x-ray diffraction (XRD), thermal analysis (DSC), functional group analysis (FTIR), solubility test, and dissolution test. The all gliclazide SE microparticlesexhibited particle size smaller than pure …
Analisis Adduct Dna Setelah Pemberian Natrium Nitrit Dan Dimetilamin Secara Berulang Pada Tikus, Sherly Meilianti, Yahdiana Harahap, Hayun Hayun
Analisis Adduct Dna Setelah Pemberian Natrium Nitrit Dan Dimetilamin Secara Berulang Pada Tikus, Sherly Meilianti, Yahdiana Harahap, Hayun Hayun
Majalah Ilmu Kefarmasian
Nitrosodimethylamine is a carcinogenic compound which can be formed from the reaction of nitrite and dimethylamine that is found in food. Nitrosodimethylamineis activated in liver and alkylates the DNA base and producing a DNA adductssuch as O6-methylguanine and N7-methylguanine that have a role incarcinogenesis. In this research, DNA was isolated from rat’s blood which waspreviously given nitrosodimethylamine’s precursor, sodium nitrite anddimethylamine. DNA adducts can be obtained from hydrolysis in hydrochloricacid 0.1 N for 30 minutes at 7000C. Then the adducts were analyzed using High Performance Liquid Chromatography (HPLC), with a strong cation exchangecolumn (Supelcosil LC-SCX, 5 μm, 250 x 4.6 …
Efek Antidiabetes Dan Identifikasi Senyawa Dominan Fraksi Kloroform Herba Ciplukan (Physalis Angulata L.), Sediarso Sediarso, Hadi Sunaryo, Nurul Amalia
Efek Antidiabetes Dan Identifikasi Senyawa Dominan Fraksi Kloroform Herba Ciplukan (Physalis Angulata L.), Sediarso Sediarso, Hadi Sunaryo, Nurul Amalia
Majalah Ilmu Kefarmasian
Antidiabetic activity of ciplukan (Physalis angulataL.) herb has a lot to do, as an extracts and infusions, proven to reduce blood sugar levels in rats or mice induced by alloxan. The research objective was to evaluate the antidiabetic effect and identify the content of the chloroform fraction ciplukan herb eluated with methanol-ammonia. Antidiabetic effects testing conducted using 30 male white mice (Mus musculus) ddY strain were divided into 6 groups, each consisting of 5 mice. K-1 is a negative control induced by alloxan, K-2, K-3 and K-4 induced by alloxan and treated with the test substance dose of 50 mg/kg …