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Uji Penghambatan Tirosinase Dan Stabilitas Fisik Sediaan Krim Pemutih Yang Mengandung Ekstrak Kulit Batang Nangka (Artocarpus Heterophyllus), Ninin Kartika Juwita, Joshita Djajadisastra, Azizahwati Azizahwati

Majalah Ilmu Kefarmasian

The cortex of jackfruit (Artocarpus heterophyllus) contains some flavonoids which have activity as tyrosinase inhibitors. This compound can inhibit the oxidation of l-tyrosine and levodopa in the mechanism of melanogenesis. The extract of jackfruit cortex formulated into creams differentiated by the extract concentration of 1,5% and 2,0%. Physical stability test was conducted with storing the creams at three different temperatures, 7 ± 2°, 27 ± 2°, and 40±2°C respectively. Centrifugal tests and cycling test was also performed on both cream. Tyrosinase inhibitory activity measurement was done by in vitro studies with measuring dopachrome. The result showed that both of formulations …