Medicine and Health Sciences Commons^™

The Development Of Preclinical Strategies For Facilitation Of Lead Candidate Selection, Christopher Dale Kulczar

Open Access Dissertations

Chapter 1 details a background of techniques used for modeling the blood-brain barrier (BBB). The BBB represents a diffusive barrier to both paracellular and transcellular movement of many compounds in and out of the brain. The main rate- limiting barriers of the BBB include exclusive tight junctions that prevent the movement of hydrophilic molecules through intercellular gaps, and efflux proteins in the membrane which pump many hydrophobic molecules back into the blood. In addition, the BBB contains metabolizing enzymes, including Cytochrome P450s. This barrier acts to protect the vulnerable tissues of the brain from harmful xenobiotics, but also can serve …

Innovative Novel Immunotherapies For The Treatment Of Glioblastoma Multiforme, Salma Salem

Open Access Theses

Glioblastoma Multiforme GBM is a very aggressive type of malignant brain tumors that affects peoples’ lives. The diffusive, infiltrative, and metastatic behaviour of GBM is the major reason for the disease recurrence. The morphological and immunohistological characteristics of Central Nervous System (CNS) tumors including GBM are heterogeneous. GBM is either primary (de novo) or secondary to low-grade astrocytomas.

Current treatment options include surgery, radiotherapy, and temozolomide chemotherapy have not achieved any improvement in success rates over the past decades. The survival time reached by GBM patients was approximately 12 months only after being treated with radiotherapy alone without temozolomide. However, …

Profile Interview With Faculty Mentor Jane Krause, Elizabeth J. Dowell, Ashley M. Schinker

Purdue Journal of Service-Learning and International Engagement

No abstract provided.

Improving Mental Health Of Elementary School Children, Alexa Proctor

Purdue Journal of Service-Learning and International Engagement

Alexa Proctor is an advanced practice student on clinical rotations with the Purdue University College of Pharmacy. In this article, she describes her experience working with Mental Health America (MHA) of Tippecanoe County and third grade children, in addition to her passion to help improve mental health in students of all ages.

Learning To Sew: A Student Pharmacist’S Service-Learning Experience, Karolina M. Grzesiak, Craig A. Vargo, Ellen M. Schellhase, Monica L. Miller, Rakhi Karwa, Sonak D. Pastakia, Beatrice Jakait

Purdue Journal of Service-Learning and International Engagement

Karolina Grzesiak is a fourth-year professional student in the College of Pharmacy at Purdue University and will earn her Doctor of Pharmacy degree in May 2017. She was raised in Poland but has called La Porte, Indiana home for the past eight years. Craig Vargo is a 2012 pharmacy graduate working as a clinical specialist pharmacist at the James Cancer Hospital at The Ohio State University Wexner Medical Center in Columbus, Ohio.

A Road Less Traveled: My Experience With Peer Advisors For Veteran Education, Mckenna Jennings

Purdue Journal of Service-Learning and International Engagement

In this article, Mckenna Jennings, a third-year PharmD student at Purdue University, describes her experience with the Peer Advisors for Veteran Education (PAVE) program, developed under the University of Michigan Military Support Programs and Networks. She also explains her motivation for involvement and the opportunity for others to become involved.

The Johns Hopkins Hospital: A Summer Internship, Adam Smith

Purdue Journal of Service-Learning and International Engagement

Adam Smith, a native of Richmond, Indiana, is an advanced pharmacy practice student in the College of Pharmacy at Purdue University. In this article, he describes how career exploration through a summer internship with The Johns Hopkins Hospital in Baltimore, Maryland solidified his desire to pursue a career in pharmacy administration.

Connecting Volunteerism To A Career: My Journey With The American Cancer Society And Pharmacy, Christine Kane

Purdue Journal of Service-Learning and International Engagement

Christine Kane is a 2016 graduate from the Purdue College of Pharmacy. In this article, she describes how two passions, the profession of pharmacy and volunteerism with the American Cancer Society, became intertwined to change the course of her career. She implores fellow students to never underestimate the impact an extracurricular activity can have on the rest of your life.

Design, Optimization, And Characterization Of Novel Polymer-Based Formulations For Controlled Release Of Drugs, Mario Alberto Cano Vega

Open Access Theses

Pharmaceutical products are a key aspect of treatment and prevention of disease. For example, dibenzazepine (DBZ) is a drug that has proved to be useful for the treatment of obesity while progesterone is a common drug for hormonal replacement therapy in women. However, administration of these drugs by conventional dosage forms offers little control over the drug distribution and concentration in the body and often result in unintended adverse consequences on other cells/tissues.

Recent advances in nanotechnology and polymer science have enabled the design and development of controlled release systems that would allow spatiotemporal delivery of drugs with improved efficacy. …

Modeling Picking On Pharmaceutical Tablets, Shrikant Swaminathan

Open Access Dissertations

Tablets are the most popular solid dosage form in the pharmaceutical industry because they are cheap to manufacture, chemically and mechanically stable and easy to transport and fairly easy to control dosage. Pharmaceutical tableting operations have been around for decades however the process is still not well understood. One of the common problems faced during the production of pharmaceutical tablets by powder compaction is sticking of powder to the punch face, This is known as 'sticking'. A more specialized case of sticking is picking when the powder is pulled away form the compact in the vicinity of debossed features. In …

Pharmacy Research On Medication Disposal Practices Using Service-Learning, Patricia L. Darbishire, Anne Packard, Maryam Noureldin, Sumaya Bahrami

Engagement & Service-Learning Summit

Abstract

The purpose was to engage students in local communities to determine what types of medications commonly go unused, discover common medication disposal practices, gauge the public’s opinion on medication disposal, and collect unwanted medications.

Student pharmacists and a faculty mentor hosted 15 medication take-back events in conjunction with community partners, and administered a survey to participants exploring disposal practices, opinions and returned medication(s). Educational brochures on safe disposal methods were distributed to participants.

Four hundred and seventy-eight surveys were collected and 4,993 medications were identified and analyzed. The top three reasons for bringing medications to collection events included: medication …

Student And Community Perceptions On Reasons For Medication Non-Adherence, Patricia L. Darbishire, Daraoun Mashrah

Engagement & Service-Learning Summit

Abstract

The purpose of this research was to improve medication adherence by exploring and reflecting on differences in the perceptions of pharmacy students and the public regarding factors contributing to medication non-adherence.

Two hundred eighty six pharmacy students and 310 patients participated in this study. Patients were recruited by pharmacy students from Midwest community pharmacies, while the students completed an experiential rotation. Students identified their patients based on evidence of non-adherence from medication profiles and asked patients to participate in the assignment. Data was collected over a four-year period, resulting in two years of information on patient perceptions and two …

Development Of A Pharmacy Service-Learning Course About Vulnerable And Underserved Patient Care, Josephine P. Aranda, Jeffrey D. Luke, Kimberly S. Plake

Engagement & Service-Learning Summit

No abstract provided.

Drug Abuse/Addiction Education (Phrm 316): A Service-Learning Course, Elizabeth J. Dowell, Ashley M. Schinker, Jane E. Krause, Richard M. Van Rijn, Val J. Watts

Engagement & Service-Learning Summit

No abstract provided.