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Inhibitory Effect Of Phytochemicals Towards Sars-Cov-2 Papain Like Protease (Plpro) Proteolytic And Deubiquitinase Activity, Anasha Kawall, Devin S M Lewis, Avini Sharma, Krishna Chavada, Rahul Deshmukh, Srujana Rayalam, Vicky Mody, Shashidharamurthy Taval
Inhibitory Effect Of Phytochemicals Towards Sars-Cov-2 Papain Like Protease (Plpro) Proteolytic And Deubiquitinase Activity, Anasha Kawall, Devin S M Lewis, Avini Sharma, Krishna Chavada, Rahul Deshmukh, Srujana Rayalam, Vicky Mody, Shashidharamurthy Taval
PCOM Scholarly Papers
Recent studies have shown that RNA-dependent RNA polymerase (RdRp), 3-chymotrypsin-like protease (3CLpro), and papain-like protease (PLpro) are necessary for SARS-CoV-2 replication. Among these three enzymes, PLpro exhibits both proteolytic and deubiquitinase (DUB) activity and is responsible for disrupting the host's innate immune response against SARS-CoV-2. Because of this unique property of PLpro, we investigated the inhibitory effects of phytochemicals on the SARS-CoV-2 PLpro enzyme. Our data indicates that the phytochemicals such as catechin, epigallocatechin gallate (EGCG), mangiferin, myricetin, rutin, and theaflavin exhibited inhibitory activity with IC50 values of 14.2, 128.4, 95.3, 12.1, and 43.4, and 7.3 μM, respectively, towards …