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Sharksrx Newsletter Fall 2021, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Sharksrx Newsletter Summer 2021, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Male Bias In Ace2 Basic Science Research: Missed Opportunity For Discovery In The Time Of Covid-19, Branka Miličić Stanić, Sydney Maddox, Aline M. De Souza, Xie Wu, Danial Mehranfard, Hong Ji, Robert C. Speth, Kathryn Sandberg

HPD Articles

Throughout the world, including the United States, men have worse outcomes from COVID-19 than women. SARS-CoV-2, the causative virus of the COVID-19 pandemic, uses angiotensin-converting enzyme 2 (ACE2) to gain cellular entry. ACE2 is a member of the renin-angiotensin system (RAS) and plays an important role in counteracting the harmful effects mediated by the angiotensin type 1 receptor. Therefore, we conducted Ovid MEDLINE and Embase database searches of basic science studies investigating the impact of the biological variable of sex on ACE2 expression and regulation from 2000, the year ACE2 was discovered, through December 31, 2020. Out of 2,131 publications, …

Chronic Administration Of Pharmacological Doses Of Angiotensin 1-7 And Iodoangiotensin 1-7 Has Minimal Effects On Blood Pressure, Heart Rate, And Cognitive Function Of Spontaneously Hypertensive Rats, Filipe F. Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C. Speth

HPD Articles

Cardiovascular diseases are the principal cause of death worldwide, with hypertension being the most common cardiovascular disease risk factor. High blood pressure (BP) is also associated with an increased risk of poor cognitive performance and dementia including Alzheimer's disease. Angiotensin 1-7 (Ang 1-7), a product of the renin-angiotensin system (RAS), exhibits central and peripheral actions to reduce BP. Recent data from our lab reveals that the addition of a non-radioactive iodine molecule to the tyrosine in position 4 of Ang 1-7 (iodoAng 1-7) makes it ~1000-fold more potent than Ang 1-7 in competing for the I-Ang 1-7 binding site (Stoyell-Conti …

Discovery Of Molecular Interactions Of The Human Melanocortin-4 Receptor (Hmc4r) Asp189 (D189) Amino Acid With The Endogenous G-Protein-Coupled Receptor (Gpcr) Antagonist Agouti-Related Protein (Agrp) Provides Insights To Agrp's Inverse Agonist Pharmacology At The Hmc4r, Mark D. Ericson, Erica M. Haslach, Sathya M. Schnell, Katie T. Freeman, Zhimin M. Xiang, Frederico P. Portillo, Robert Speth, Sally A. Litherland, Carrie Haskell-Luevano

HPD Articles

The melanocortin receptors (MCRs) are important for numerous biological pathways, including feeding behavior and energy homeostasis. In addition to endogenous peptide agonists, this receptor family has two naturally occurring endogenous antagonists, agouti and agouti-related protein (AGRP). At the melanocortin-4 receptor (MC4R), the AGRP ligand functions as an endogenous inverse agonist in the absence of agonist and as a competitive antagonist in the presence of agonist. At the melanocortin-3 receptor (MC3R), AGRP functions solely as a competitive antagonist in the presence of agonist. The molecular interactions that differentiate AGRP's inverse agonist activity at the MC4R have remained elusive until the findings …

Nsu Cop Students On Rotations Contribute To The Vaccination Efforts, Silverman College Of Pharmacy

Archived News and Events

Broward Health Medical Center began administering the COVID19 vaccine to healthcare workers, EMS and patients aged 65 and over in January 2021. They opened a community vaccination site at Inter Miami CF Stadium in Fort Lauderdale. NSU students taking introductory and advanced pharmacy practice rotations within a Broward Health Hospital or Clinic had an opportunity to contribute to the vaccination effort.

NSU P4 student Angela Sanichar immunized her preceptor and alumni, Dr. Kaleed Mohammed ('09), Regional Manager of Pharmacy Services at Broward Health. Dr. Mohammed said, "Vaccine dose number 2 done! How cool is it to have your student give …

Alterations In Gene Expression Of Renin-Angiotensin System Components And Related Proteins In Colorectal Cancer, Danial Mehranfard, Gabriela Perez, Andres Rodriguez, Julia M. Ladna, Christopher T. Neagra, Benjamin Goldstein, Timothy Carroll, Alice Tran, Malav Trivedi, Robert C. Speth

HPD Articles

MATERIALS AND METHODS: Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip arrays from the public functional genomics data repository, Gene Expression Omnibus (GEO) application, was compared statistically. RESULTS: Expression of four genes, (angiotensinogen), (aminopeptidase A) (neprilysin), and (prolyl endopeptidase), was significantly upregulated in CRC specimens. Expression of (renin), (thimet oligopeptidase), (neurolysin), (prolyl carboxypeptidase), (aminopeptidase N), and (Mas receptor) was downregulated in CRC specimens. CONCLUSIONS: Presuming gene expression parallel protein expression, these results suggest that increased production of the angiotensinogen precursor of angiotensin (ANG) peptides, with the reduction of the enzymes that …

Nsu College Of Pharmacy_Brochure_2021, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.