Medicine and Health Sciences Commons^™

Analysis Of Molecular Changes In 2 Types Of Non-Tumor Adjacent Breast Identified By Nucleotide Excision Repair In Early Stage Breast Cancer, Manasi Ramesh Pimpley

Student Theses, Dissertations and Capstones

NER plays an important role in remediating DNA damage. Latimer et al., have previously shown nucleotideexcision repair (NER) to be intrinsically deficient in stage I sporadic BC by function and gene expression. Previous work performed on 12 isogenically matched stage I tumors and non-tumor adjacent (NTA) samples identified 2 types of NTA tissue with regard to functional NER. One type that represented 75% ofthe samples, had lower NER capacity, similar to the tumor (Low: Low pair). The other type had high NER relative to the tumor (High: Low pair). Two isogenic NTA/tumor cell line pairs representing these 2 types ofNTA …