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Full-Text Articles in Medicine and Health Sciences
Enzymatic Pathways Of The Brain Renin-Angiotensin System: Unsolved Problems And Continuing Challenges, Vardan T. Karamyan, Robert C. Speth
Enzymatic Pathways Of The Brain Renin-Angiotensin System: Unsolved Problems And Continuing Challenges, Vardan T. Karamyan, Robert C. Speth
HPD Articles
The brain renin-angiotensin system continues to be enigmatic more than 40 years after the brain was first recognized to be a site of action of angiotensin II. This review focuses on the enzymatic pathways for the formation and degradation of the growing number of active angiotensins in the brain. A brief description and nomenclature of the peptidases involved in the processing of angiotensin peptides in the brain is given. Of primary interest is the array of enzymes that degrade radiolabeled angiotensins in receptor binding assays. This poses major challenges to studies of brain angiotensin receptors and it is debatable whether …
Placental Insufficiency Results In Temporal Alterations In The Renin Angiotensin System In Male Hypertensive Growth Restricted Offspring, Daniela Grigore, Norma B. Ojeda, Elliot B. Robertson, Antoinette S. Dawson, Contrina A. Huffman, Erick A. Bourassa, Robert C. Speth, K Bridget Brosnihan, Barbara T. Alexander
Placental Insufficiency Results In Temporal Alterations In The Renin Angiotensin System In Male Hypertensive Growth Restricted Offspring, Daniela Grigore, Norma B. Ojeda, Elliot B. Robertson, Antoinette S. Dawson, Contrina A. Huffman, Erick A. Bourassa, Robert C. Speth, K Bridget Brosnihan, Barbara T. Alexander
HPD Articles
Reduced uterine perfusion initiated in late gestation in the rat results in intrauterine growth restriction (IUGR) and development of hypertension by 4 wk of age. We hypothesize that the renin angiotensin system (RAS), a regulatory system important in the long-term control of blood pressure, may be programmed by placental insufficiency and may contribute to the etiology of IUGR hypertension. We previously reported that RAS blockade abolished hypertension in adult IUGR offspring; however, the mechanisms responsible for the early phase of hypertension are unresolved. Therefore, the purpose of this study was to examine RAS involvement in early programmed hypertension and to …
Prevention Of Angiotensin Ii-Induced Cardiac Remodeling By Angiotensin-(1-7), Justin L. Grobe, Adam P. Mecca, Melissa Lingis, Vinayak Shenoy, Tonya A. Bolton, Juline M. Machado, Robert C. Speth, Mohan K. Raizada, Michael J. Katovich
Prevention Of Angiotensin Ii-Induced Cardiac Remodeling By Angiotensin-(1-7), Justin L. Grobe, Adam P. Mecca, Melissa Lingis, Vinayak Shenoy, Tonya A. Bolton, Juline M. Machado, Robert C. Speth, Mohan K. Raizada, Michael J. Katovich
HPD Articles
Cardiac remodeling, which typically results from chronic hypertension or following an acute myocardial infarction, is a major risk factor for the development of heart failure and, ultimately, death. The renin-angiotensin system (RAS) has previously been established to play an important role in the progression of cardiac remodeling, and inhibition of a hyperactive RAS provides protection from cardiac remodeling and subsequent heart failure. Our previous studies have demonstrated that overexpression of angiotensin-converting enzyme 2 (ACE2) prevents cardiac remodeling and hypertrophy during chronic infusion of angiotensin II (ANG II). This, coupled with the knowledge that ACE2 is a key enzyme in the …
Health Professions Division Catalog 2007-2008, Nova Southeastern University
Health Professions Division Catalog 2007-2008, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
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