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Full-Text Articles in Medicine and Health Sciences
Chronic Administration Of Pharmacological Doses Of Angiotensin 1-7 And Iodoangiotensin 1-7 Has Minimal Effects On Blood Pressure, Heart Rate, And Cognitive Function Of Spontaneously Hypertensive Rats, Filipe F. Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C. Speth
Chronic Administration Of Pharmacological Doses Of Angiotensin 1-7 And Iodoangiotensin 1-7 Has Minimal Effects On Blood Pressure, Heart Rate, And Cognitive Function Of Spontaneously Hypertensive Rats, Filipe F. Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C. Speth
HPD Articles
Cardiovascular diseases are the principal cause of death worldwide, with hypertension being the most common cardiovascular disease risk factor. High blood pressure (BP) is also associated with an increased risk of poor cognitive performance and dementia including Alzheimer's disease. Angiotensin 1-7 (Ang 1-7), a product of the renin-angiotensin system (RAS), exhibits central and peripheral actions to reduce BP. Recent data from our lab reveals that the addition of a non-radioactive iodine molecule to the tyrosine in position 4 of Ang 1-7 (iodoAng 1-7) makes it ~1000-fold more potent than Ang 1-7 in competing for the I-Ang 1-7 binding site (Stoyell-Conti …
Sex-Specific Modulation Of Blood Pressure And The Renin-Angiotensin System By Ace (Angiotensin-Converting Enzyme) 2, Hong Ji, Aline M. De Souza, Bilkish Bajaj, Wei Zheng, Xie Wu, Robert C. Speth, Kathryn Sandberg
Sex-Specific Modulation Of Blood Pressure And The Renin-Angiotensin System By Ace (Angiotensin-Converting Enzyme) 2, Hong Ji, Aline M. De Souza, Bilkish Bajaj, Wei Zheng, Xie Wu, Robert C. Speth, Kathryn Sandberg
HPD Articles
We showed ACE (angiotensin-converting enzyme) 2 is higher in the kidney of male compared with female mice. To further investigate this sex difference, we examined the role of ACE2 in Ang-[1-8] (angiotensin [1-8])-induced hypertension and regulation of the renin-angiotensin system in the kidney of WT (wild type) and Ace2 KO (knockout) mice. Mean arterial pressure rose faster in WT male than WT female mice after Ang-[1-8] infusion. This sex difference was attenuated in ACE2 KO mice. Ang-[1-8] infusion reduced glomerular AT1R (angiotensin type 1 receptor) binding in WT female mice by 30%, and deletion of abolished this effect. In contrast, …