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Chronic Administration Of Pharmacological Doses Of Angiotensin 1-7 And Iodoangiotensin 1-7 Has Minimal Effects On Blood Pressure, Heart Rate, And Cognitive Function Of Spontaneously Hypertensive Rats, Filipe F. Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C. Speth
Chronic Administration Of Pharmacological Doses Of Angiotensin 1-7 And Iodoangiotensin 1-7 Has Minimal Effects On Blood Pressure, Heart Rate, And Cognitive Function Of Spontaneously Hypertensive Rats, Filipe F. Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C. Speth
HPD Articles
Cardiovascular diseases are the principal cause of death worldwide, with hypertension being the most common cardiovascular disease risk factor. High blood pressure (BP) is also associated with an increased risk of poor cognitive performance and dementia including Alzheimer's disease. Angiotensin 1-7 (Ang 1-7), a product of the renin-angiotensin system (RAS), exhibits central and peripheral actions to reduce BP. Recent data from our lab reveals that the addition of a non-radioactive iodine molecule to the tyrosine in position 4 of Ang 1-7 (iodoAng 1-7) makes it ~1000-fold more potent than Ang 1-7 in competing for the I-Ang 1-7 binding site (Stoyell-Conti …