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Species And Tissue-Specificity Of Prokinetic, Laxative And Spasmodic Effects Of Fumaria Parviflora, Najeeb-Ur-Rehman, Malik Hassan Mehmood, Adnan J. Al-Rehaily, Ramzi A. A. Mothana, Anwar H. Gilani

Department of Biological & Biomedical Sciences

Background: Fumaria parviflora Linn. (Fumariaceae), is a small branched annual herb found in many parts of the world including Saudi Arabia and Pakistan. This study was designed to provide pharmacological basis for the medicinal use of Fumaria parviflora in gut motility disorders. Methods: The in-vivo prokinetic and laxative assays were conducted in mice. Isolated intestinal preparations (ileum and jejunum) from different animal species (mouse, guinea-pig and rabbit) were separately suspended in tissue baths containing Tyrode's solution bubbled with carbogen and maintained at 37 degrees C. The spasmogenic responses were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results: …