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Full-Text Articles in Medicine and Health Sciences
35ci Solid-State Nmr Characterization Of Polymorphs And Cocrystals Of Xylazine Hci, Louae M. Abdulla
35ci Solid-State Nmr Characterization Of Polymorphs And Cocrystals Of Xylazine Hci, Louae M. Abdulla
Electronic Theses and Dissertations
Xylazine HCl (X), a common veterinary analgesic, has four reported polymorphs that are stable under ambient conditions, Form A (Xa), Form X (Xx), Form Z (Xz), and Form M (Xm), and one monohydrate (Xh). A commercial sample of X was found to contain mixtures of polymorphs and previous synthetic approaches proved unreliable and/or unsuccessful for the production of pure phases in high yields. Herein, we report methods for the reliable preparation and interconversion of polymorphs of X (including mechanochemical synthetic pathways), the discovery of a novel polymorph (Xy), and synthesis of three novel cocrystals with coformers containing amide and carboxylic …
Assessing The Accuracy And Deficits Of Popular Drug-Interaction Software Programs In Detecting Interactions Between Cannabis And Pharmaceutical Drugs, Nathan C. Ramsbacher
Assessing The Accuracy And Deficits Of Popular Drug-Interaction Software Programs In Detecting Interactions Between Cannabis And Pharmaceutical Drugs, Nathan C. Ramsbacher
Undergraduate Theses, Professional Papers, and Capstone Artifacts
- Purpose – The management of drug interactions in healthcare is a large concern for pharmacists and other healthcare professionals, especially for patients requiring large amounts of medications. Healthcare professionals and patients alike utilize drug-interaction software programs (DISPs) frequently to manage medications and make clinical decisions. There is a large discrepancy between DISPs in terms of detecting clinically significant drug interactions. Notably, cannabis does not flag as an interaction as reliably as pharmaceutical drugs on many DISPs. With rising cannabis use in the United States, patients deserve to make decisions on how to safely use cannabis with their prescription drugs …