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Full-Text Articles in Medicine and Health Sciences
Formulary Status Of Cephalosporins, Agnes J. Renault
Formulary Status Of Cephalosporins, Agnes J. Renault
University of the Pacific Theses and Dissertations
The primary purpose of this study is to analyze the formulary status of cephalosporins among a representative sample of hospitals in the United States. In addition, the research design attempts to determine the ranking of cephalsoporins in terms of acceptance to the hospitals' formulary and actual stocking of the cephaosoporin products. The study will attempt to ascertain the reasons for these rankings and the influence of DRG implementation, teaching status and hospital bed size on number of cephalosporins on formulary and in stock. This may yield insight into the strategies that hospitals are currently using to contain a significant proportion …
Design And Evaluation Of Theophylline Monitoring For Home Health Care Patients, May Naim Mikhail
Design And Evaluation Of Theophylline Monitoring For Home Health Care Patients, May Naim Mikhail
University of the Pacific Theses and Dissertations
The purpose of this study was to design, evaluate, and determine the cost benefit of a pharmacokinetic service for home-based patients. Four randomly selected patient populations were used in evaluating the service for six months. The experimental group consisted of 17 patients who were under the care of family practice physicians in private practice and who received pharmacokinetic consultation and monitoring by a pharmacist as a home health care service. The retrospective control consisted of the same 17 patients of the experimental group whose past medical history for a period of six months was used. The concurrent control consisted of …
Investigation Of Physicochemical And Formulation Parameters For Transdermal Delivery Of Isoproterenol Hc1, Rajesh Arvindkumar Patel
Investigation Of Physicochemical And Formulation Parameters For Transdermal Delivery Of Isoproterenol Hc1, Rajesh Arvindkumar Patel
University of the Pacific Theses and Dissertations
Effects of solubility, partition coefficient, pH and selected adjuvants (propylene glycol and Azone) on the percutaneous penetration of isoproterenol HC1 in vitro have been investigated using human cadaver skin. Preliminary stability studies demonstrated that isoproterenol HC1 was very stable (less than 1% decomposition) for 24 hours at 22(DEGREES) (+OR-) 0.5(DEGREES) in the pH range 1 to 7 in the following solvents: water, normal saline, propylene glycol and a series of propylene glycol-water mixtures (10,20,40 and 60% v/v). The rate of decomposition of the drug in aqueous solutions increased with pH beyond pH 8. In normal saline, the decomposition was significant …
Opioid Receptor Effects Of Two Aminotetralin Derivatives In Guinea Pig Ileum Longitudinal Muscle And Mouse Vas Deferens Preparations, Francisca Fatima Matos
Opioid Receptor Effects Of Two Aminotetralin Derivatives In Guinea Pig Ileum Longitudinal Muscle And Mouse Vas Deferens Preparations, Francisca Fatima Matos
University of the Pacific Theses and Dissertations
Two substituted analogs of 3-amino-2,2-dimethyltetralin, namely 3-dimethylamino-7-hydroxy-2,2-dimethyl-1-tetralone HBr (J) and 3-dimethylamino-7-hydroxy-2,2-dimethyl-1-tetralol (MRSAL) were evaluated for opioid agonist and antagonist activity using the electrically-stimulated guinea pig ileum longitudinal muscle and mouse vas deferens preparations. The effects of these compounds in these tissues were compared to those induced by several opioid prototype agonists at mu, kappa and delta sites (normorphine, dihydromorphine, ethylketocyclazocine, U-50,488H, beta -endorphin, dynorphin 1-13, leu-enkephalin and DADLE) and one opioid antagonist (naloxone). The results of these experiments demonstrated that compound J inhibited contractions in a concentration-dependent manner as an opioid agonist and its effects were antagonized by naloxone in …