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Influence Of Novel Techniques On Solubility, Mechanical Properties And Permeability Via Hot Melt Extrusion Technology, Eman A. Ashour
Influence Of Novel Techniques On Solubility, Mechanical Properties And Permeability Via Hot Melt Extrusion Technology, Eman A. Ashour
Electronic Theses and Dissertations
Hot melt extrusion (HME) was evaluated as a continuous processing technology for the manufacture of solid dispersions. The aim of the current research project was to study the effect of pressurized carbon dioxide (P-CO2) on the physico-mechanical properties of three different grades of cellulose polymers, Klucel™ ELF, EF and LF hydroxypropylcellulose (HPC) resulting from hot melt extrusion techniques, and to assess the plasticization effect of P-CO2 on the tested polymers. The physico-mechanical properties as well as the tablet characteristics of the extrudates with and without injection of P-CO2 and with non-extruded polymers were examined. P-CO2 acted as plasticizer for Klucel™ …