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Protein-Ligand Interaction Studies And Identification Of New Drug-Like Hits As Cannabinoid Receptor Modulators, Pankaj Pandey
Protein-Ligand Interaction Studies And Identification Of New Drug-Like Hits As Cannabinoid Receptor Modulators, Pankaj Pandey
Electronic Theses and Dissertations
The cannabinoid receptors (CB1 and CB2) belong to the family of class A GPCRs. The CB1 receptor is predominately found in the central nervous system and regulates various neuromodulatory and physiological processes while CB2 receptors are found in peripheral tissues, particularly in the immune system tissues. This dissertation reports several projects including: (1) an examination of the putative binding modes of Cannabis-derived ligands with CB1 and CB2 receptors, (2) the identification of novel CB1 inverse agonists, and (3) the identification of allosteric site(s) in the CB2 receptor and screening of new CB2 allosteric modulators (AMs).
Chapter 1 describes background information …