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Full-Text Articles in Medicine and Health Sciences
Injectable Systems For Long-Lasting Insulin Therapy, Kumar Kulldeep Niloy
Injectable Systems For Long-Lasting Insulin Therapy, Kumar Kulldeep Niloy
Theses and Dissertations (ETD)
Diabetes mellitus is one of the major global health problems and the prevalence rate is ever increasing reaching to 48% increase by the year of 2040 causing significant economic burdens. Insulin therapy has been the mainstay of diabetes treatment since its discovery in 1922. However, insulin is an unstable peptide with a half-life of only 4-6 min which poses significant challenge in prolonging duration of action of insulin. Nevertheless, the advances in recombinant DNA technology and protein engineering have enabled the development of several long-acting insulin analogue products which show duration of action up to 42 h. However, these insulin …
Controlled Release Of Insulin And Modified Insulin From A Novel Injectable Biodegradable Gel, Om Anand
Controlled Release Of Insulin And Modified Insulin From A Novel Injectable Biodegradable Gel, Om Anand
Theses and Dissertations (ETD)
The objective of the study was to develop a controlled release dosage form of
insulin, which can provide basal concentrations of insulin in diabetic rats for 1 to 2 weeks after a single subcutaneous injection.
A biodegradable injectable drug delivery gel was prepared by dissolving a
biodegradable polymer, polylactic-co-glycolic acid (PLGA), in biocompatible
plasticizer(s), triethyl citrate (TEC) and/or acetyl triethyl citrate (ATEC). Insulin was
then loaded into the blank gel to form an insulin suspension in the polymer solution.
After the insulin-loaded gel was injected subcutaneously, the plasticizer(s) dissolved in the aqueous media and were gradually taken away from the …