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Articles 1 - 30 of 40
Full-Text Articles in Medicine and Health Sciences
Research News. Publications, 2020. Volume 4, Soumyajit Majumdar
Research News. Publications, 2020. Volume 4, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period October 1 through December 31, 2020
Clinical Relevance Of Cancer Stem Cell Chemotherapeutic Assay For Recurrent Ovarian Cancer, Candace M. Howard, Nadim Bou Zgheib, Stephen Bush, Timothy Deeulis, Antonio Cortese, Antonio Mollo, Seth T. Lirette, Krista Denning, Jagan Valluri, Pier Paolo Claudio
Clinical Relevance Of Cancer Stem Cell Chemotherapeutic Assay For Recurrent Ovarian Cancer, Candace M. Howard, Nadim Bou Zgheib, Stephen Bush, Timothy Deeulis, Antonio Cortese, Antonio Mollo, Seth T. Lirette, Krista Denning, Jagan Valluri, Pier Paolo Claudio
Faculty and Student Publications
© 2020 Introduction: Disease recurrence and progression of ovarian cancer is common with the development of platinum-resistant or refractory disease. This is due in large part to the presence of chemo-resistant cancer stem cells (CSCs) that contribute to tumor propagation, maintenance, and treatment resistance. We developed a CSCs drug cytotoxicity assay (ChemoID) to identify the most effective chemotherapy treatment from a panel of FDA approved chemotherapies. Methods: Ascites and pleural fluid samples were collected under physician order from 45 consecutive patients affected by 3rd-5th relapsed ovarian cancer. Test results from the assay were used to treat patients with the highest …
Financial Analysis Of Dalbavancin For Acute Bacterial Skin And Skin Structure Infections For Self-Pay Patients, Adam G. Pizzuti, E. Yancy Murray, Jamie L. Wagner, Derek A. Gaul, Christopher M. Bland, Bruce M. Jones
Financial Analysis Of Dalbavancin For Acute Bacterial Skin And Skin Structure Infections For Self-Pay Patients, Adam G. Pizzuti, E. Yancy Murray, Jamie L. Wagner, Derek A. Gaul, Christopher M. Bland, Bruce M. Jones
Faculty and Student Publications
© 2020, The Author(s). Introduction: Acute bacterial skin and skin structure infections (ABSSSI) are an increasing cause of admission in the self-pay population. We previously reported that patients with ABSSSI discharged to receive dalbavancin showed a decreased length of stay (LOS) and total direct costs without increasing 30-day readmission rate. For patients who are financially eligible, a dalbavancin vial replacement program can offset costs. The objective of this study was to determine cost differences in treating ABSSSI in self-pay inpatients discharged to receive dalbavancin compared to standard of care (SOC). Methods: This retrospective cohort within a community health system compared …
Condylar Neck And Sub-Condylar Fractures: Surgical Consideration And Evolution Of The Technique With Short Follow-Up On Five Cases, Antonio Cortese, Antonio Borri, Marco Bergaminelli, Fabrizio Bergaminelli
Condylar Neck And Sub-Condylar Fractures: Surgical Consideration And Evolution Of The Technique With Short Follow-Up On Five Cases, Antonio Cortese, Antonio Borri, Marco Bergaminelli, Fabrizio Bergaminelli
Faculty and Student Publications
Condylar neck and sub-condylar fractures of the mandible are a frequent occurrence in maxillofacial surgery. The indication for surgical treatment of these fractures has changed over time, and several techniques have been developed with different results in the attempt to avoid the most worrisome adverse event, i.e., facial nerve injury. In this study, we present a new technique that combines an intraoral and a cutaneous pre-auricular access, which allows for easy and safe access to the surgical site, preventing facial nerve injury and avoiding surgical scars in high-impact aesthetic areas of the neck. Five consecutive patients affected by condylar neck …
A New Stilbene From Agonis Flexuosa Leaves And Verification Of Its Histamine Release Inhibitory Activity Using In Silico And In Vitro Studies, Rola M. Labib, Lourin G. Malak, Fadia S. Youssef, Samir A. Ross
A New Stilbene From Agonis Flexuosa Leaves And Verification Of Its Histamine Release Inhibitory Activity Using In Silico And In Vitro Studies, Rola M. Labib, Lourin G. Malak, Fadia S. Youssef, Samir A. Ross
Faculty and Student Publications
This study aimed to explore the phytoconstituents of Agonis flexuosa, F. Myrtaceae and its biological activity. A thorough phytochemical investigation of its leaves led to the isolation of one new stilbene glycoside; (Z)-2,3-dihydroxystilbene-5-O-β-D-glucoside (1), and fifteen known compounds identified as two stilbenes: (Z)-pinosylvin mono methyl ether (2) and (Z)-pinosylvin-3-O-β-D-glucoside (3); six flavanones: (2S)-pinostrobin (4), (2S)-strobopinin (5), (2S)-cryptostobin (6), (2S)-pinocembrin (7), (2S)-dimethylpinocembrin (8) and (2S)-dimethylstrobopinin (9); four flavonoids: quercetin (10), kaempferol-7-O-β-D-glucoside (11), quercetin-3-O-α-D-rhamnoside (12) and quercetin-3-O-β-D-glucoside (13), α-terpineol (14), β-sitosterol (15) and gallic acid (16). The structures of the isolated metabolites were elucidated based upon the interpretation of their 1D and …
Discovery Of A Remarkable Methyl Shift Effect In The Vanilloid Activity Of Triterpene Amides, Rosa Maria Vitale, Cristina Avonto, Danilo Del Prete, Aniello Schiano Moriello
Discovery Of A Remarkable Methyl Shift Effect In The Vanilloid Activity Of Triterpene Amides, Rosa Maria Vitale, Cristina Avonto, Danilo Del Prete, Aniello Schiano Moriello
Faculty and Student Publications
As part of a study on triterpenoid conjugates, the dietary pentacyclic triterpenoids oleanolic (2a) and ursolic acids (3a) were coupled with vanillamine, and the resulting amides (2b and 3b, respectively) were assayed for activity on the vanilloid receptor TRPV1. Despite a structural difference limited to the location of a methyl group in their conformationally rigid pentacyclic core, oleanoloyl vanillamide dramatically outperformed ursoloyl vanillamide in terms of potency (EC50 = 35 ± 2 nM for 2b and 5.4 ± 2.3 μM for 3b). Using molecular docking and dynamics, this difference was translated into distinct accommodation modes at the TRPV1 vanillyl ligand …
Redox-Responsive Nanoplatform For Codelivery Of Mir-519c And Gemcitabine For Pancreatic Cancer Therapy, Xiaofei Xin, Virender Kumar, Feng Lin, Vinod Kumar, Rajan Bhattarai, Vijaya R. Bhatt, Chalet Tan, Ram I. Mahato
Redox-Responsive Nanoplatform For Codelivery Of Mir-519c And Gemcitabine For Pancreatic Cancer Therapy, Xiaofei Xin, Virender Kumar, Feng Lin, Vinod Kumar, Rajan Bhattarai, Vijaya R. Bhatt, Chalet Tan, Ram I. Mahato
Faculty and Student Publications
Copyright © 2020 The Authors, some rights reserved. Desmoplastic and hypoxic pancreatic cancer microenvironment induces aberrant expression of miRNAs and hypoxia-inducible factor-1α (HIF-1α) responsible for gemcitabine (GEM) resistance. We demonstrated that miR-519c was down-regulated in pancreatic cancer and transfection of miR-519c in GEM-resistant pancreatic cancer cells inhibited HIF-1α level under hypoxia. We synthesized redox-sensitive mPEG-co-P(Asp)-g-DC-g-S-S-GEM polymer, with GEM payload of 14% (w/w) and 90% GEM release upon incubation with l-glutathione. We synthesized mPEGco- P(Asp)-g-TEPA-g-DC for complex formation with miRNA. Chemical modification of miR-519c with 2'-O-methyl phosphorothioate (OMe-PS) at 3' end enhanced its stability and activity without being immunogenic. Epidermal growth …
Real-World Patterns Of Everolimus Use In Patients With Metastatic Breast Cancer, Manvi Sharma, Zhigang Duan, Hui Zhao, Sharon H. Giordano, Mariana Chavez-Macgregor
Real-World Patterns Of Everolimus Use In Patients With Metastatic Breast Cancer, Manvi Sharma, Zhigang Duan, Hui Zhao, Sharon H. Giordano, Mariana Chavez-Macgregor
Faculty and Student Publications
© AlphaMed Press 2020 Background: There is limited literature on patterns of everolimus use and subsequent hospitalizations and emergency room (ER) visits in real-world clinical practice. In this study, we describe patterns of everolimus use and hospitalizations and ER visits in a large cohort of patients with breast cancer (BC). Materials and Methods: Patients with BC treated with everolimus were identified in the MarketScan database from 2009 to 2016. The pattern of everolimus use and frequency of associated ER visits and hospitalizations during treatment (between the first claim and 30 days after the last claim for everolimus) were identified. Descriptive …
Research News. Publications, 2020. Volume 3, Soumyajit Majumdar
Research News. Publications, 2020. Volume 3, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period July 1 through September 30, 2020
Research News. Grants, 2020. Volume 3, Soumyajit Majumdar
Research News. Grants, 2020. Volume 3, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during July - September 2020
Novel Compounds In Fruits Of Coriander (Coşkuner & Karababa) With Anti-Inflammatory Activity, Renyikun Yuan, Zhenjie Liu, Jianping Zhao, Qin Qin Wang, Aiyuan Zuo, Liting Huang, Hongwei Gao, Qiongming Xu, Ikhlas A. Khan, Shilin Yang
Novel Compounds In Fruits Of Coriander (Coşkuner & Karababa) With Anti-Inflammatory Activity, Renyikun Yuan, Zhenjie Liu, Jianping Zhao, Qin Qin Wang, Aiyuan Zuo, Liting Huang, Hongwei Gao, Qiongming Xu, Ikhlas A. Khan, Shilin Yang
Faculty and Student Publications
© 2020 Coriander, Coriandrum Sativum L., is one of the commonest food and medicinal plants in many countries, but its chemical ingredients and pivotal role in anti-inflammatory activity have not been fully explored. The present study aimed to identify new compounds in the fruits of coriander and explore their anti-inflammatory activity. The compounds were isolated by chromatographic seperations and identified using spectroscopic and spectrometric methods. RAW264.7 macrophage cells were used to detect the anti-inflammatory activity of the compounds via Griess assay, western blotting, ELISA, and flow cytometry methods. The study resulted in the discovery of four new compounds, which were …
Marine Antithrombotics, Rohini Dwivedi, Vitor H. Pomin
Marine Antithrombotics, Rohini Dwivedi, Vitor H. Pomin
Faculty and Student Publications
Thrombosis remains a prime reason of mortality worldwide. With the available antithrombotic drugs, bleeding remains the major downside of current treatments. This raises a clinical concern for all patients undergoing antithrombotic therapy. Novel antithrombotics from marine sources offer a promising therapeutic alternative to this pathology. However, for any potential new molecule to be introduced as a real alternative to existing drugs, the exhibition of comparable anticoagulant potential with minimal off-target effects must be achieved. The relevance of marine antithrombotics, particularly sulfated polysaccharides, is largely due to their unique mechanisms of action and lack of bleeding. There have been many investigations …
Validating A Predictive Model Of Cannabinoid Inheritance With Feral, Clinical, And Industrial Cannabis Sativa, Jonathan P. Wenger, Clemon J. Dabney, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Chandrani G. Majumdar, George D. Weiblen
Validating A Predictive Model Of Cannabinoid Inheritance With Feral, Clinical, And Industrial Cannabis Sativa, Jonathan P. Wenger, Clemon J. Dabney, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Chandrani G. Majumdar, George D. Weiblen
Faculty and Student Publications
© 2020 The Authors. American Journal of Botany published by Wiley Periodicals LLC on behalf of Botanical Society of America Premise: How genetic variation within a species affects phytochemical composition is a fundamental question in botany. The ratio of two specialized metabolites in Cannabis sativa, tetrahydrocannabinol (THC) and cannabidiol (CBD), can be grouped into three main classes (THC-type, CBD-type, and intermediate type). We tested a genetic model associating these three groups with functional and nonfunctional alleles of the cannabidiolic acid synthase gene (CBDAS). Methods: We characterized cannabinoid content and assayed CBDAS genotypes of >300 feral C. sativa plants in Minnesota, …
Screening For More Than 1,000 Pesticides And Environmental Contaminants In Cannabis By Gc/Q-Tof, Philip L. Wylie, Jessica Westland, Mei Wang, Mohamed M. Radwan
Screening For More Than 1,000 Pesticides And Environmental Contaminants In Cannabis By Gc/Q-Tof, Philip L. Wylie, Jessica Westland, Mei Wang, Mohamed M. Radwan
Faculty and Student Publications
A method has been developed to screen cannabis extracts for more than 1,000 pesticides and environmental pollutants using a gas chromatograph coupled to a high-resolution accurate mass quadrupole time-of-flight mass spectrometer (GC/Q-TOF). An extraction procedure was developed using acetonitrile with solid phase extraction cleanup. Before analysis, extracts were diluted 125:1 with solvent. Two data mining approaches were used together with a retention-time-locked Personal Compound Database and Library (PCDL) containing high-resolution accurate mass spectra for pesticides and other environmental pollutants. (1) A Find-by-Fragments (FbF) software tool extracts several characteristic exact mass ions within a small retention time window where the compound …
Research News. Publications, 2020. Volume 2, Soumyajit Majumdar
Research News. Publications, 2020. Volume 2, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period April 1 through June 30, 2020
Research News. Grants, 2020. Volume 2, Soumyajit Majumdar
Research News. Grants, 2020. Volume 2, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during April - June 2020
School Of Pharmacy Intellectual Property Report Fy20, Fourth Quarter Report, Soumyajit Majumdar
School Of Pharmacy Intellectual Property Report Fy20, Fourth Quarter Report, Soumyajit Majumdar
U. S. Patents, School of Pharmacy
School of Pharmacy Intellectual Property Report FY20, Fourth Quarter Report (as of 6/30/20)
Expression Of Poly-Adp-Ribose Polymerase (Parp) In Endometrial Adenocarcinoma: Prognostic Potential, Logan M. Lawrence, Rebecca Russell, Claire E. Denning, Nadim Bou Zgheib, Travis Salisbury, Seth T. Lirette, Jagan Valluri, Pier Paolo Claudio, Krista L. Denning
Expression Of Poly-Adp-Ribose Polymerase (Parp) In Endometrial Adenocarcinoma: Prognostic Potential, Logan M. Lawrence, Rebecca Russell, Claire E. Denning, Nadim Bou Zgheib, Travis Salisbury, Seth T. Lirette, Jagan Valluri, Pier Paolo Claudio, Krista L. Denning
Faculty and Student Publications
© 2020 Background: In the United States endometrial carcinoma is the most common female gynecologic malignancy. An average of more than 60,000 new cases of endometrial carcinomas have been diagnosed yearly over the past 5 years, with a higher incidence occurring in the central Appalachian states of Ohio and West Virginia. In the U.S., the national average of newly diagnosed endometrial carcinomas is 26.8 in every 100,000 women, while in the states of Ohio and West Virginia the average is 30.5 and 31.1 in every 100,000 women, respectively. This notable increase in the incidence of endometrial carcinomas may be due …
Extracellular Matrix Components Isolated From Diabetic Mice Alter Cardiac Fibroblast Function Through The Age/Rage Signaling Cascade, Stephanie D. Burr, James A. Stewart
Extracellular Matrix Components Isolated From Diabetic Mice Alter Cardiac Fibroblast Function Through The Age/Rage Signaling Cascade, Stephanie D. Burr, James A. Stewart
Faculty and Student Publications
© 2020 The Authors Individuals suffering from diabetes have an increased risk of developing cardiovascular complications such as heart failure. Heart failure can be a result of the stiffening of the left ventricle, which occurs when cardiac fibroblasts become “active” and begin to remodel the extracellular matrix (ECM). Fibroblast “activation” can be triggered by the AGE/RAGE signaling cascade. Advanced Glycation End products (AGEs) are produced and accumulate in the ECM over time in a healthy individual, but under hyperglycemic conditions, this process is accelerated. In this study, we investigated how the presence of AGEs in either non-diabetic or diabetic ECM …
Fluoroquinolone Versus Nonfluoroquinolone Treatment Of Bloodstream Infections Caused By Chromosomally Mediated Ampc‐Producing Enterobacteriaceae, Sarah Grace Gunter, Katie E. Barber, Jamie L. Wagner, Kayla R. Stover
Fluoroquinolone Versus Nonfluoroquinolone Treatment Of Bloodstream Infections Caused By Chromosomally Mediated Ampc‐Producing Enterobacteriaceae, Sarah Grace Gunter, Katie E. Barber, Jamie L. Wagner, Kayla R. Stover
Faculty and Student Publications
Objectives: Chromosomally mediated AmpC-producing Enterobacteriaceae (CAE) display high susceptibility to fluoroquinolones; minimal clinical data exist supporting comparative clinical outcomes. The objective of this study was to compare treatment outcomes between fluoroquinolone and nonfluoroquinolone definitive therapy of bloodstream infections caused by CAE. Methods: This retrospective cohort assessed adult patients with positive blood cultures for CAE that received inpatient treatment for 48 hours. The primary outcome was difference in clinical failure between patients who received fluoroquinolone (FQ) versus non‐FQ treatment. Secondary endpoints included microbiological cure, infection‐related length of stay, 90‐day readmission, and all‐cause inpatient mortality. Results: 56 patients were included in the …
Multicenter, Observational Cohort Study Evaluating Third-Generation Cephalosporin Therapy For Bloodstream Infections Secondary To Enterobacter, Serratia, And Citrobacter Species, Caroline Derrick, P. Brandon Bookstaver, Zhiqiang K. Lu, Christopher M. Bland
Multicenter, Observational Cohort Study Evaluating Third-Generation Cephalosporin Therapy For Bloodstream Infections Secondary To Enterobacter, Serratia, And Citrobacter Species, Caroline Derrick, P. Brandon Bookstaver, Zhiqiang K. Lu, Christopher M. Bland
Faculty and Student Publications
Objectives: There is debate on whether the use of third-generation cephalosporins (3GC) increases the risk of clinical failure in bloodstream infections (BSIs) caused by chromosomally-mediated AmpC-producing Enterobacterales (CAE). This study evaluates the impact of definitive 3GC therapy versus other antibiotics on clinical outcomes in BSIs due to Enterobacter, Serratia, or Citrobacter species. Methods: This multicenter, retrospective cohort study evaluated adult hospitalized patients with BSIs secondary to Enterobacter, Serratia, or Citrobacter species from 1 January 2006 to 1 September 2014. Definitive 3GC therapy was compared to definitive therapy with other non-3GC antibiotics. Multivariable Cox proportional hazards regression evaluated the impact of …
Pregnane Steroidogenesis Is Altered By Hiv-1 Tat And Morphine: Physiological Allopregnanolone Is Protective Against Neurotoxic And Psychomotor Effects, Jason Paris, Philippe Lière, Sarah Kim, Fakhri Mahdi, Meagen E. Buchanan, Sara R. Nass, Alaa N. Qrareya, Mohammed F. Salahuddin, Antoine Pianos, Neïké Fernandez, Zia Shariat-Madar, Pamela E. Knapp, Michaël Schumacher, Kurt F. Hauser
Pregnane Steroidogenesis Is Altered By Hiv-1 Tat And Morphine: Physiological Allopregnanolone Is Protective Against Neurotoxic And Psychomotor Effects, Jason Paris, Philippe Lière, Sarah Kim, Fakhri Mahdi, Meagen E. Buchanan, Sara R. Nass, Alaa N. Qrareya, Mohammed F. Salahuddin, Antoine Pianos, Neïké Fernandez, Zia Shariat-Madar, Pamela E. Knapp, Michaël Schumacher, Kurt F. Hauser
Faculty and Student Publications
Pregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexplored in vivo, AlloP may confer protection against the neurological dysfunction associated with human immunodeficiency virus type 1 (HIV-1). The HIV-1 regulatory protein, trans-activator of transcription (Tat), is neurotoxic and its expression in mice increases anxiety-like behavior; an effect that can be ameliorated by progesterone, but not when 5α-reduction is blocked. Given that Tat's neurotoxic effects involve mitochondrial dysfunction and can be worsened with opioid exposure, we hypothesized that Tat and/or combined morphine would perturb steroidogenesis in mice, promoting neuronal death, and that exogenous AlloP would …
Concordance Between Electronic Health Record Data And Medicare Part D Claims Data For Oral Anticancer Drug Use, Manvi Sharma, Michael L. Johnson, Hui Zhao, Sharon H. Giordano, Holly M. Holmes
Concordance Between Electronic Health Record Data And Medicare Part D Claims Data For Oral Anticancer Drug Use, Manvi Sharma, Michael L. Johnson, Hui Zhao, Sharon H. Giordano, Holly M. Holmes
Faculty and Student Publications
Real-world evidence from electronic health records (EHRs) and claims data are being evaluated for use in regulatory decision-making.1,2 The objective of our study was to determine the concordance between EHR and Medicare Part D (MPD) claims data for the receipt of oral anticancer agents, a rapidly growing treatment option for cancer.
Research News. Grants, 2020. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Research News. Grants, 2020. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during January - March 2020
School Of Pharmacy Intellectual Property Report Fy20, Third Quarter Report, Soumyajit Majumdar
School Of Pharmacy Intellectual Property Report Fy20, Third Quarter Report, Soumyajit Majumdar
U. S. Patents, School of Pharmacy
School of Pharmacy Intellectual Property Report FY20, Third Quarter Report (as of 3/31/2020)
A Public Health Issue: Dietary Supplements Promoted For Brain Health And Cognitive Performance, Cindy Crawford, Courtney Boyd, Bharathi Avula, Yan Hong Wang, Ikhlas A. Khan, Patricia A. Deuster
A Public Health Issue: Dietary Supplements Promoted For Brain Health And Cognitive Performance, Cindy Crawford, Courtney Boyd, Bharathi Avula, Yan Hong Wang, Ikhlas A. Khan, Patricia A. Deuster
Faculty and Student Publications
© Cindy Crawford, et al. 2020; Published by Mary Ann Liebert, Inc. 2020. Background: Dietary supplements targeting brain health have quickly emerged in the marketplace as cognitive performance becomes an important public health issue. While manufacturers are required to report the exact ingredients and formulations listed on the Supplement Facts labels of products, many reports have indicated such labels are not always truthful, and the content of some products is inconsistent with the ingredients listed on the Supplement Facts label. Objectives: To identify dietary supplement products and ingredients marketed for brain health and cognitive performance and perform analyses of select …
Cancer Stem Cell Chemotherapeutics Assay For Prospective Treatment Of Recurrent Glioblastoma And Progressive Anaplastic Glioma: A Single-Institution Case Series, Tulika Ranjan, Candace M. Howard, Alexander Yu, Linda Xu, Khaled Aziz, David Jho, Jodi Leonardo, Muhammad A. Hameed, Stephen M. Karlovits, Rodney E. Wegner, Russell Fuhrer, Seth T. Lirette, Krista L. Denning, Jagan Valluri, Pier Paolo Claudio
Cancer Stem Cell Chemotherapeutics Assay For Prospective Treatment Of Recurrent Glioblastoma And Progressive Anaplastic Glioma: A Single-Institution Case Series, Tulika Ranjan, Candace M. Howard, Alexander Yu, Linda Xu, Khaled Aziz, David Jho, Jodi Leonardo, Muhammad A. Hameed, Stephen M. Karlovits, Rodney E. Wegner, Russell Fuhrer, Seth T. Lirette, Krista L. Denning, Jagan Valluri, Pier Paolo Claudio
Faculty and Student Publications
© 2020 BACKGROUND: Chemotherapy-resistant cancer stem cells (CSC) may lead to tumor recurrence in glioblastoma (GBM). The poor prognosis of this disease emphasizes the critical need for developing a treatment stratification system to improve outcomes through personalized medicine. METHODS: We present a case series of 12 GBM and 2 progressive anaplastic glioma cases from a single Institution prospectively treated utilizing a CSC chemotherapeutics assay (ChemoID) guided report. All patients were eligible to receive a stereotactic biopsy and thus undergo ChemoID testing. We selected one of the most effective treatments based on the ChemoID assay report from a panel of FDA …
Concordance Between Electronic Health Record Data And Medicare Part D Claims Data For Oral Anticancer Drug Use, Manvi Sharma, Michael L. Johnson, Hui Zhao, Sharon H. Giordano, Holly M. Holmes
Concordance Between Electronic Health Record Data And Medicare Part D Claims Data For Oral Anticancer Drug Use, Manvi Sharma, Michael L. Johnson, Hui Zhao, Sharon H. Giordano, Holly M. Holmes
Faculty and Student Publications
No abstract provided.
Promising Selective Mao-B Inhibition By Sesamin, A Lignan From Zanthoxylum Flavum Stems, Shaymaa M. Mohamed, Narayan D. Chaurasiya, Nesma M. Mohamed, Soad A.L. Bayoumi, Babu L. Tekwani, Samir A. Ross
Promising Selective Mao-B Inhibition By Sesamin, A Lignan From Zanthoxylum Flavum Stems, Shaymaa M. Mohamed, Narayan D. Chaurasiya, Nesma M. Mohamed, Soad A.L. Bayoumi, Babu L. Tekwani, Samir A. Ross
Faculty and Student Publications
© 2020 The Author(s) Monoamine oxidase inhibition is an important therapeutic approach for various neurodegenerative disorders. Reversible MAO inhibitors selectively targeting only one isoform possess substantial merit in terms of safety, efficacy, and side effect profile. This study aimed to isolate the secondary metabolites of Zanthoxylum flavum stems and evaluate their recombinant human MAO inhibition, antimicrobial, and antiprotozoal activities. As a result, fourteen compounds were isolated and identified (nine of them were reported from Z. flavum for the first time). Compound 3 (sesamin) exhibited potent selective MAO-B inhibition (IC50 value of 1.45 ± 0.05 µM) which reported herein for the …
Research News. Publications, 2020. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Research News. Publications, 2020. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period January 1 through March 31, 2020