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Full-Text Articles in Medicine and Health Sciences
The Roles Of Osteopontin In The Pathogenesis Of West Nile Encephalitis, Farzana Nazneen, Fengwei Bai
The Roles Of Osteopontin In The Pathogenesis Of West Nile Encephalitis, Farzana Nazneen, Fengwei Bai
Faculty Publications
Osteopontin (OPN), a multifunctional protein encoded by the secreted phosphoprotein-1 (Spp-1) gene in humans, plays important roles in a variety of physiological conditions, such as biomineralization, bone remodeling and immune functions. OPN also has significant roles in the pathogenesis of autoimmune, allergy and inflammatory diseases, as well as bacterial, fungal and viral infections. West Nile virus (WNV), a mosquito-transmitted flavivirus, is the leading agent for viral encephalitis in North America. Recent progress has been made in understanding both the biological functions of OPN and the pathogenesis of WNV. In this review article, we have summarized the current understanding of the …
Recent Advances In Stimuli-Responsive Drug Release And Targeting Concepts Using Mesoporous Silica Nanoparticles, Ghada G. Abdo, Moustafa M. Zagho, Ashraf Khalil
Recent Advances In Stimuli-Responsive Drug Release And Targeting Concepts Using Mesoporous Silica Nanoparticles, Ghada G. Abdo, Moustafa M. Zagho, Ashraf Khalil
Faculty Publications
Being a developed and promising approach, nanotechnology has attracted a lot of attention in biomedical and pharmaceutical therapy applications. Among nanostructured materials, mesoporous silica nanoparticles (MSNs) are effectively used as nanocarriers for drug delivery systems. MSNs can be tailored-designed by different synthetic techniques. Their morphological characteristics dictate the type of application of such materials. Recently, polymer-based materials have been employed to functionalize the MSNs surface. These modified nanocarriers are loaded with the drug and can unload their “cargo” upon exposure to either endogenous or exogenous types of stimuli. In this study, different targeting concepts, including passive, active, vascular, nuclear, and …