Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Amorphous solid dispersion (1)
- Antinociceptive activity (1)
- Anxiety (1)
- Crystallinity (1)
- Drug delivery (1)
-
- Fentanyl (1)
- Fluorescent bioassay (1)
- GABAA receptor allosteric modulators (1)
- Gene delivery (1)
- Glass transition temperature (1)
- Hydrogen bonding (1)
- Immune modulation (1)
- Liposome (1)
- MOR antagonist (1)
- Naltrexone (1)
- Physical stability (1)
- Solid-state nuclear magnetic resonance spectroscopy (1)
- Structure-activity relationship (1)
- Terpene synthase engineering (1)
- Vaccines (1)
- Yeast engineering (1)
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Building Tools For Improved Modulation Of The Human Gabaa Receptor, A Central Nervous System Target For The Treatment Of Anxiety, Garrett Edward Zinck
Building Tools For Improved Modulation Of The Human Gabaa Receptor, A Central Nervous System Target For The Treatment Of Anxiety, Garrett Edward Zinck
Theses and Dissertations--Pharmacy
In the U.S., anxiety is recognized as an increasing range of mentally and physically debilitating psychiatric health disorders with significant economic repercussions. Over the last 20 years, several novel anti-anxiety therapies have entered the drug development pipeline, but none have made it to market.
The work in this dissertation focused on structurally modifying valerenic acid (VA), a structurally unique carboxylated sesquiterpene acid found in Valeriana officinalis. VA is putatively reported to have allosteric modulatory activity of the human GABAA receptor, a ligand-gated ion channel responsible for attenuating neurotransmissions. Structural modeling of VA’s GABAA receptor interaction suggests that …
Studies Toward The Development Of An Improved Countermeasure For Synthetic Opioid Overdose, Sidnee L. Hedrick
Studies Toward The Development Of An Improved Countermeasure For Synthetic Opioid Overdose, Sidnee L. Hedrick
Theses and Dissertations--Pharmacy
One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropriately, however, ingestion of just a few milligrams of fentanyl or other synthetic opioid can cause opioid-induced respiratory depression (OIRD), often leading to death. Currently, the treatment of choice for OIRD is the opioid receptor antagonist naloxone. Recent reports, however, suggest that higher doses or repeated dosing of naloxone (due to recurrence of respiratory depression) may be required to fully reverse fentanyl-induced respiratory depression, rendering …
Investigating The Physical Stability Of Amorphous Pharmaceutical Formulations, Travis W. Jarrells
Investigating The Physical Stability Of Amorphous Pharmaceutical Formulations, Travis W. Jarrells
Theses and Dissertations--Pharmacy
Amorphous formulations, including amorphous solid dispersions (ASDs), consisting of the active pharmaceutical ingredient (API) intimately mixed in a polymeric matrix, are an attractive formulation approach to improve drug delivery, dissolution, and solubility. However, an amorphous API in an ASD is in a higher energy state compared to the crystalline drug and results in most ASDs being inherently unstable. The polymer helps to stabilize the amorphous drug against crystallization such that the resulting homogenous mixture maintains its solubility advantage relative to the crystalline form. One challenge of ASDs is that the presence of impurities including crystals or residual solvent, variations in …
Liposomal Technologies To Improve Gene Delivery, David Nardo Padron
Liposomal Technologies To Improve Gene Delivery, David Nardo Padron
Theses and Dissertations--Pharmacy
Lipid based nanoparticles (LBNs) are used in myriad applications in medicine from small molecule drug delivery to mRNA vaccines. A major contributing factor to the development of the field has been the ongoing development of novel compounds that retain the functionality of natural lipids but expand upon them through inclusion of functional moieties that can be applied to specific scientific and biomedical questions. In the body of this dissertation, an extensive overview of LBNs is provided, focusing primarily on their use in immune modulation. The research presented herein begins with the synthesis of a novel class of lipids based on …