Medicine and Health Sciences Commons^™

Concordance Of Regional Hypoperfusion By Pcasl Mri And 15O-Water Pet In Frontotemporal Dementia: Is Pcasl An Efficacious Alternative?, Tracy Ssali, Lucas Narciso, Justin Hicks, Linshan Liu, Sarah Jesso, Lauryn Richardson, Matthias Günther, Simon Konstandin, Klaus Eickel, Frank Prato, Udunna C. Anazodo, Elizabeth Finger, Keith St Lawrence

Paediatrics Publications

Background: Clinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap of symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is a promising non-invasive alternative to established PET techniques; however, its sensitivity to imaging parameters can hinder its ability to detect perfusion abnormalities. Purpose: This study evaluated the similarity of regional hypoperfusion patterns detected by ASL relative to the gold standard for imaging perfusion, PET with radiolabeled water (15O-water). Methods and materials: Perfusion by single-delay pseudo continuous ASL (SD-pCASL), free-lunch Hadamard encoded pCASL (FL_TE-pCASL), and 15O-water data were acquired …