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Childhood nephrotic syndrome;; Frequent-relapse steroid-sensitive nephrotic syndrome;; Rituximab;; Second-line immunosuppressive treatment;; Steroid-dependent nephrotic syndrome;; Steroid-resistant nephrotic syndrome;; Tacrolimus
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Full-Text Articles in Medicine and Health Sciences
Second-Line Immunosuppressive Treatment Of Childhood Nephrotic Syndrome: A Single-Center Experience, J. Kim, N. Patnaik, N. Chorny, R. Frank, L. Infante, C. Sethna
Second-Line Immunosuppressive Treatment Of Childhood Nephrotic Syndrome: A Single-Center Experience, J. Kim, N. Patnaik, N. Chorny, R. Frank, L. Infante, C. Sethna
Journal Articles
OBJECTIVE: Most cases of idiopathic nephrotic syndrome in childhood are responsive to corticosteroids. However, there is a small group of children that demonstrate steroid resistance (steroid-resistant nephrotic syndrome; SRNS), steroid dependence, or that frequently relapse (frequent-relapse steroid-sensitive nephrotic syndrome; FR-SSNS) which are more clinically difficult to treat. Therefore, second-line immunosuppressants, such as alkylating agents, calcineurin inhibitors, antimetabolites and, more recently, rituximab, have been used with varying success. The objective was to evaluate the response rates of various second-line therapies in the treatment of childhood nephrotic syndrome. STUDY DESIGN: A retrospective chart review of pediatric subjects with idiopathic nephrotic syndrome was …