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- Acquired immunodeficiency syndrome (AIDS) (1)
- Aga Khan University Hospital (1)
- Aga Khan University Hospital Nairobi (1)
- Antiretroviral drug resistance (1)
- Colorectal cancer (1)
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- Family history (1)
- HIV-1 (1)
- Human immunodeficiency virus (HIV) (1)
- Hypertension (1)
- Hypertriglyceridaemia (1)
- Immunohistochemistry (1)
- Kenya (1)
- Low HDL cholesterol (1)
- Microsatellite instability (1)
- Mismatch repair proteins (1)
- Nairobi (1)
- Obesity (1)
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- Type 2 diabetes (1)
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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Early Onset Type 2 Diabetes And Associated Risk Factors, Grace Nyambura Kiraka
Early Onset Type 2 Diabetes And Associated Risk Factors, Grace Nyambura Kiraka
Theses & Dissertations
Background: The incidence of type 2 diabetes in patients below the age of 40 (early onset diabetes) is markedly on the rise and has been linked increased prevalence of risk factors such as the metabolic syndrome and family history of diabetes.
Objective: To determine the proportion of patients with type 2 diabetes at Aga Khan University Hospital Nairobi (AKUHN) who have early onset type 2 diabetes and the association of age of onset with risk factors (family history of diabetes, obesity, waist circumference, hypertension, low HDL cholesterol and hypertriglyceridaemia) in this group of patients.
Methods: This was a …
Expression Of Mismatch Repair Proteins In Colorectal Cancer At Aga Khan University Hospital, Nairobi, Charles M. Wahome
Expression Of Mismatch Repair Proteins In Colorectal Cancer At Aga Khan University Hospital, Nairobi, Charles M. Wahome
Theses & Dissertations
Introduction: Microsatellite instability is one of three molecular pathways described in the pathogenesis of colorectal carcinoma. The presence of microsatellite instability in patients with colorectal cancer has implications for prognosis and family counselling. Deficiency in mismatch repair genes leads to microsatellite instability and this can be reliably demonstrated in formalin fixed paraffin embedded tissue by methods, which include immunohistochemistry for the detection of mismatch repair proteins.
Local data show a disproportionately large number of younger patients with colorectal cancer compared to that documented in Caucasians. Colorectal cancer in younger ages is often attributed to deficient mismatch repair.
The objective of …
Primary Antiretroviral Drug Resistance Profiles Among Hiv-1 Therapy Naïve Patients In Two Referral Hospitals In Kenya, Simon Onsongo Nyangena
Primary Antiretroviral Drug Resistance Profiles Among Hiv-1 Therapy Naïve Patients In Two Referral Hospitals In Kenya, Simon Onsongo Nyangena
Theses & Dissertations
Objective: To characterize antiretroviral drug resistance mutations among drug naïve patients in two referral hospitals in Kenya
Background: Acquired immunodeficiency syndrome (AIDS) caused by Human immunodeficiency virus (HIV) was first described in 1982. Since then the virus has spread globally to infect millions of people. HIV was first described in Kenya in the period between 1984/1985. Currently, Kenya has an estimated HIV-1 prevalence of 6.2% with a country population of about 40 million people. With the introduction of antiretroviral drugs, the survival of most HIV patients has been prolonged markedly. However this is greatly threatened by increasing rates of antiretroviral …