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Full-Text Articles in Medicine and Health Sciences
Pd-1 Expression On Immune Cells In Sepsis Mouse Model And The Susceptibility To Secondary Fungal Infection, Chau Tran Bao Vu
Pd-1 Expression On Immune Cells In Sepsis Mouse Model And The Susceptibility To Secondary Fungal Infection, Chau Tran Bao Vu
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: This study aimed to i) determine the kinetic changes of immune cell phenotypes, including an exhaustion marker PD-1, in spleens of murine sepsis ii) investigate the susceptibility against secondary fungal infection after sepsis, and iii) investigate the efficacy of an anti-PD-1 treatment in post-sepsis fungal infection. Methods: Cecal ligation and puncture (CLP) was used as a sepsis model and splenocytes post-CLP were assessed by flow cytometry. In addition, secondary post sepsis systemic fungal infections by Candida albicans or Aspergillus fumigatus administration at 5-day post-CLP were performed. Moreover, secondary aspergillosis was treated with Amphotericin B with or without anti-PD-1 to …
Tlr3 Signaling Modulates Immunomodulatory Property Of Human Periodontal Ligament Stem Cells., Daneeya Chaikiawkeaw
Tlr3 Signaling Modulates Immunomodulatory Property Of Human Periodontal Ligament Stem Cells., Daneeya Chaikiawkeaw
Chulalongkorn University Theses and Dissertations (Chula ETD)
Toll like receptor 3 (TLR3) is a member of TLR family functions to recognizes double-stranded RNA (dsRNA) produced by positive-strand RNA viruses and DNA virusesand generate signaling that stimulate body immune system against virus infection. However, recent evidence suggests that TLR3 signaling may also play a role in initiating the immunosuppressive property of the cells. Study on skin regeneration has shown the anti-inflammatory responses of keratinocytes required for wound healing andthe increasing number of hair follicle formation after TLR3 signaling was activated by fragment of RNA released from damaged cells. Moreover, activation of TLR3 signaling have shown to elicit a …
Effect Of Cyclic Tensile Force On The Expression Of Bone Morphogenetic Protein 9 And Interleukin 6 In Human Periodontal Ligament Cells, Yanee Tantilertanant
Effect Of Cyclic Tensile Force On The Expression Of Bone Morphogenetic Protein 9 And Interleukin 6 In Human Periodontal Ligament Cells, Yanee Tantilertanant
Chulalongkorn University Theses and Dissertations (Chula ETD)
Periodontium is a specialized tissue laying between tooth and surrounding bone. It functions as force cushion. In particular stimulation including mechanical force, periodontal ligament (PDL) cells which are mechanosensitive cells have the ability to secrete specific cytokines and proteins. PDL cells also have the potential to differentiate into osteoblast-like cells or fibroblast-like cells. PDL cells perceive combination of force in oral cavity in which major component is cyclic tensile force (CTF). CTF play an essential role in modulating PDL cells to maintain both hard and soft tissue integrity. Here, we demonstrated that CTF was able to stimulate the expression of …