Medicine and Health Sciences Commons^™

Hyperthermia, Radiation And Chemotherapy: The Role Of Heat In Multidisciplinary Cancer Care., Mark Hurwitz, Md, Paul R. Stauffer

Department of Radiation Oncology Faculty Papers

The compelling biologic basis for combining hyperthermia with modern cancer therapies including radiation and chemotherapy was first appreciated nearly half a century ago. Hyperthermia complements radiation as conditions contributing to radio-resistance generally enhance sensitivity to heat and sensitizing effects occur through increased perfusion/tumor oxygenation and alteration of cellular death pathways. Chemosensitization with hyperthermia is dependent on the particular mechanism of effect for each agent with synergistic effects noted for several commonly used agents. Clinically, randomized trials have demonstrated benefit including survival with the addition of hyperthermia to radiation or chemotherapy in treatment of a wide range of malignancies. Improvements in …

Exploiting High-Throughput Cell Line Drug Screening Studies To Identify Candidate Therapeutic Agents In Head And Neck Cancer, Anthony C Nichols, Morgan Black, John Yoo, Nicole Pinto, Andrew Fernandes, Benjamin Haibe-Kains, Paul C Boutros, John W Barrett

Oncology Publications

BACKGROUND: There is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput drug screening techniques and next-generation sequencing have identified new therapeutic targets in other cancer types, but an HNSCC-specific study has not yet been carried out. We have exploited data from two large-scale cell line projects to clearly describe the mutational and copy number status of HNSCC cell lines and identify candidate drugs with elevated efficacy in HNSCC.

METHODS: The genetic landscape of 42 HNSCC cell lines including mutational and copy number data …

Oncolog, Volume 59, Number 09, September 2014, Stephanie Deming, Bryan Tutt, Joe Munch, Jill Deisigne

OncoLog MD Anderson's Report to Physicians (All issues)

• Biomarker-Driven Clinical Trials may Improve Personalized Treatment for Patients With Lung Cancer: Innovative clinical trials that assign patients to treatment arms based on tumor biomarkers could lead to increase treatment options for patients with lung cancer
• New Antibody-Chemotherapy Combinations Show Promise Against Acute Lymphoblastic Leukemia: Two investigational agents-inotuzumab and ofatumumab-shows promise when combined with cytotoxic chemotherapy drugs for the treatment of acute lymphoblastic leukemia (ALL) in adults
• Deep Inspiration Breath Hold Protects Against Radiation-Induced Cardiotoxicity in Patients With Left-Sided Breast cancers: Patients with lest-sided breast cancers have an increased risk of heart damage from adjuvant radiation therapy given after lumpectomy …

Methylseleninic Acid Sensitizes Notch3-Activated Ovca429 Ovarian Cancer Cells To Carboplatin., Tiffany J. Tzeng, Lei Cao, Yangxin Fu, Huawei Zeng, Wen-Hsing Cheng

College of Agriculture & Life Sciences Publications and Scholarship

Ovarian cancer, the deadliest of gynecologic cancers, is usually not diagnosed until advanced stages. Although carboplatin has been popular for treating ovarian cancer for decades, patients eventually develop resistance to this platinum-containing drug. Expression of neurogenic locus notch homolog 3 (Notch3) is associated with chemoresistance and poor overall survival in ovarian cancer patients. Overexpression of NICD3 (the constitutively active form of Notch3) in OVCA429 ovarian cancer cells (OVCA429/NICD3) renders them resistance to carboplatin treatment compared to OVCA429/pCEG cells expressing an empty vector. We have previously shown that methylseleninic acid (MSeA) induces oxidative stress and activates ataxia-telangiectasia mutated and DNA-dependent protein …

Oncolog, Volume 59, Number 07, July 2014, Sarah Bronson, Joe Munch, Bryan Tutt, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

• Side Effects of Targeted Molecular Agents Vary According to Mechanism of Action: The main side effects of cytotoxic chemotherapy are notorious. But the side effects of newer, targeted molecular agents are less well known, so patients receiving such drugs may not know what to expect and may require additional guidance from physicians
• INBRIEF: Study Finds Less Frequent Bisphosphonate Treatment Equivalent to Standard Regimen
• RAS Mutation Status May predict Outcomes After Surgery for Colorectal Cancer Liver Metastases
• HPV Test Does Not Replace Pap Test for Cervical cancer Screening: The recent approval of a human papillomavirus (HPV) test for cervical cancer screening …

Oncolog, Volume 59, Number 02, February 2014, Sarah Bronson, Kathryn L. Hale, Bryan Tutt, M. Yeoman

OncoLog MD Anderson's Report to Physicians (All issues)

• New Approaches Revolutionize the Treatment of Advanced Melanoma: Recent breakthroughs in immunotherapy and targeted therapy have improved outcomes for patients with advanced melanoma
• Comprehensive Tobacco Treatment Approach Helps Patients Quit on Their Terms: Kicking a tobacco habit is a formidable task. Quitting tobacco after a diagnosis of cancer, can be even more difficult
• Targeted Drug Shows Promise Against Advanced Breast Cancer: Adding the experimental kinase inhibitor palbociclib to standard hormonal therapy may delay disease progression in patients with advanced breast cancer that is estrogen receptor (ER) positive and human epidermal growth factor receptor 2 (HER@) negative
• HOUSE CALL: Avoiding Food-Drug …