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Cancer As A Channelopathy—Appreciation Of Complimentary Pathways Provides A Different Perspective For Developing Treatments, Harry J. Hgould@Lsuhsc.Edu Gould, Dennis Paul

School of Medicine Faculty Publications

Life depends upon the ability of cells to evaluate and adapt to a constantly changing environment and to maintain internal stability to allow essential biochemical reactions to occur. Ions and ion channels play a crucial role in this process and are essential for survival. Alterations in the expression of the transmembrane proteins responsible for maintaining ion balance that occur as a result of mutations in the genetic code or in response to iatrogenically induced changes in the extracellular environment is a characteristic feature of oncogenesis and identifies cancer as one of a constellation of diseases known as channelopathies. The classification …