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Full-Text Articles in Medicine and Health Sciences
Estrogen Regulates Mirna Expression: Implication Of Estrogen Receptor And Mir-124/Akt2 In Tumor Growth And Angiogenesis., Cheng-Fei Jiang, Dong-Mei Li, Zhu-Mei Shi, Lin Wang, Min-Min Liu, Xin Ge, Xue Liu, Ying-Chen Qian, Yi-Yang Wen, Lin-Lin Zhen, Jie Lin, Ling-Zhi Liu, Bing-Hua Jiang
Estrogen Regulates Mirna Expression: Implication Of Estrogen Receptor And Mir-124/Akt2 In Tumor Growth And Angiogenesis., Cheng-Fei Jiang, Dong-Mei Li, Zhu-Mei Shi, Lin Wang, Min-Min Liu, Xin Ge, Xue Liu, Ying-Chen Qian, Yi-Yang Wen, Lin-Lin Zhen, Jie Lin, Ling-Zhi Liu, Bing-Hua Jiang
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
It is currently known that estrogen plays an important role in breast cancer (BC) development, but the underlying molecular mechanism remains to be elucidated. Accumulating evidence has revealed important roles of microRNAs in various kinds of human cancers, including BC. In this study, we found that among the microRNAs regulated by estrogen, miR-124 was the most prominent downregulated miRNA. miR-124 was downregulated by estradiol (E2) treatment in estrogen receptor (ER) positive BC cells, miR-124 overexpression suppressed cell proliferation, migration and invasion in BC cells; while the suppression of miR-124 using Anti-miR-124 inhibitor had opposite cellular functions. Under the E2 treatment, …