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Full-Text Articles in Medicine and Health Sciences
Employing Respondent Driven Sampling (Rds) To Recruit People Who Inject Drugs (Pwid) And Other Hard-To-Reach Populations During Covid-19: Lessons Learned, Roberto Abadie, Patrick Habecker, Kimberly Gocchi Carrasco, Kathy S. Chiou, Samodha Fernando, Sydney J. Bennett, Aníbal Valentin-Acevedo, Kirk Dombrowski, John T. West, Charles Wood
Employing Respondent Driven Sampling (Rds) To Recruit People Who Inject Drugs (Pwid) And Other Hard-To-Reach Populations During Covid-19: Lessons Learned, Roberto Abadie, Patrick Habecker, Kimberly Gocchi Carrasco, Kathy S. Chiou, Samodha Fernando, Sydney J. Bennett, Aníbal Valentin-Acevedo, Kirk Dombrowski, John T. West, Charles Wood
School of Medicine Faculty Publications
Background: Respondent Driven Sampling (RDS) is an effective sampling strategy to recruit hard-to-reach populations but the impact of the COVID-19 pandemic on the use of this strategy in the collection of data involving human subjects, particularly among marginalized and vulnerable populations, is not known. Based on an ongoing study using RDS to recruit and study the interactions between HIV infection, injection drug use, and the microbiome in Puerto Rico, this paper explores the effectiveness of RDS during the pandemic and provided potential strategies that could improve recruitment and data collection. Results: RDS was employed to evaluate its effectiveness in recruiting …
Landscape Of Molecular Crosstalk Perturbation Between Lung Cancer And Covid-19, Aditi Kuchi, Jiande Wu, Jyotsna Fuloria, Chindo Hicks
Landscape Of Molecular Crosstalk Perturbation Between Lung Cancer And Covid-19, Aditi Kuchi, Jiande Wu, Jyotsna Fuloria, Chindo Hicks
School of Medicine Faculty Publications
Background: Lung cancer patients have the worst outcomes when affected by coronavirus disease 2019 (COVID-19). The molecular mechanisms underlying the association between lung cancer and COVID-19 remain unknown. The objective of this investigation was to determine whether there is crosstalk in molecular perturbation between COVID-19 and lung cancer, and to identify a molecular signature, molecular networks and signaling pathways shared by the two diseases. Methods: We analyzed publicly available gene expression data from 52 severely affected COVID-19 human lung samples, 594 lung tumor samples and 54 normal disease-free lung samples. We performed network and pathways analysis to identify molecular networks …
Severe Covid-19 Is Characterized By An Impaired Type I Interferon Response And Elevated Levels Of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells, Matthew J. Dean, Juan B. Ochoa, Maria Dulfary Sanchez-Pino, Jovanny Zabaleta, Jone Garai, Luis Del Valle, Dorota Wyczechowska, Lyndsey Buckner Baiamonte, Phaethon Philbrook, Rinku Majumder, Richard S. Vander Heide, Logan Dunkenberger, Ramesh Puttalingaiah Thylur, Bobby Nossaman, W. Mark Roberts, Andrew G. Chapple, Jiande Wu, Chindo Hicks, Jack Collins, Brian Luke
Severe Covid-19 Is Characterized By An Impaired Type I Interferon Response And Elevated Levels Of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells, Matthew J. Dean, Juan B. Ochoa, Maria Dulfary Sanchez-Pino, Jovanny Zabaleta, Jone Garai, Luis Del Valle, Dorota Wyczechowska, Lyndsey Buckner Baiamonte, Phaethon Philbrook, Rinku Majumder, Richard S. Vander Heide, Logan Dunkenberger, Ramesh Puttalingaiah Thylur, Bobby Nossaman, W. Mark Roberts, Andrew G. Chapple, Jiande Wu, Chindo Hicks, Jack Collins, Brian Luke
School of Medicine Faculty Publications
COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease. Recent reports show an increase in circulating monocytic-myeloid-derived suppressor cells (M-MDSC) in severe COVID 19 that deplete arginine but are not associated with respiratory complications. Our data shows that differences in the type, function and transcriptome of granulocytic-MDSC (G-MDSC) may in part explain the severity COVID-19, in particular the association with pulmonary complications. Large infiltrates by Arginase 1+ G-MDSC (Arg+G-MDSC), expressing NOX-1 and NOX-2 (important for production of reactive oxygen …