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Allelic Deletion On Chromosome 17p13.3 In Early Ovarian Cancer, Nancy Phillips, Michelle Ziegler, Diane Radford, Keri Fair, Todd Steinbrueck, Francisco Xynos, Helen Donis-Keller
Allelic Deletion On Chromosome 17p13.3 In Early Ovarian Cancer, Nancy Phillips, Michelle Ziegler, Diane Radford, Keri Fair, Todd Steinbrueck, Francisco Xynos, Helen Donis-Keller
Helen Donis-Keller
Multiple chromosome 17 loci may be involved in ovarian carcinogenesis. Fifty-seven sporadic ovarian epithelial tumors were examined for loss of heterozygosity at 15 loci on chromosome 17p. Eighty % (39 of 49) of informative tumors had allelic loss in 17p13.3 at D17S30, D17S28, or both loci within this region, including 3 of 7 tumors of low malignant potential and 4 of 5 nonmetastatic carcinomas. The smallest region of overlapping deletion extends from D17S28 to D17S30, a distance of 15 kb. Furthermore, several tumors have breakpoints within the region detected by the D17S30 probe. Chromosome 17p13.3 genes with potential tumor suppressor …