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A Novel In Vitro Method For Pelvic Floor Dysfunction In Pcos Women, Ruben Vila Jun 2021

A Novel In Vitro Method For Pelvic Floor Dysfunction In Pcos Women, Ruben Vila

University Honors Theses

Background:

Poly Cystic Ovary Syndrome and Pelvic Floor Dysfunction are reproductive diseases with comorbidities whose novel relationship deserves further investigation.

Methods:

Levator Ani Muscle/Paravaginal Attachment was dissected from female Rhesus Macaque and subjected to tissue dissociation. Cells were treated with serum level hormones E2, T, and DHT. PCR, ICC, and IHC were used, followed by statistical analysis.

Results:

RNA analysis show differences in relative expression for endpoints ER, PR, AR, Ki-67, Col1A, and Vimentin. IHC along with ICC showed expression and localization in vivo.

Conclusions:

A novel in vitro model was created from macaque Levator Ani Muscle/Paravaginal Attachment for Pelvic …


Characteristics Associated With Downward Residential Mobility Among Birthing Persons In California., Samantha Gailey, Rebekah Israel Cross, Lynne C. Messer, Tim A. Bruckner May 2021

Characteristics Associated With Downward Residential Mobility Among Birthing Persons In California., Samantha Gailey, Rebekah Israel Cross, Lynne C. Messer, Tim A. Bruckner

OHSU-PSU School of Public Health Faculty Publications and Presentations

Substantial research documents health consequences of neighborhood disadvantage. Patterns of residential mobility that differ by race/ethnicity and socioeconomic status (SES) may sort non-Hispanic (NH) Black and low-SES families into disadvantaged neighborhoods. In this study, we leverage a sibling-linked dataset to track residential mobility among birthing persons between pregnancies and investigate baseline characteristics associated with downward mobility, including race/ethnicity, SES, and pre-existing health conditions.