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Full-Text Articles in Medicine and Health Sciences
Association Of Plasma Afatoxin With Persistent Detection Of Oncogenic Human Papillomaviruses In Cervical Samples From Kenyan Women Enrolled In A Longitudinal Study, Yan Tong, Philip Tonui, Elkanah Orang'o, Jianjun Zhang, Titus Maina, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen, Aaron Ermel
Association Of Plasma Afatoxin With Persistent Detection Of Oncogenic Human Papillomaviruses In Cervical Samples From Kenyan Women Enrolled In A Longitudinal Study, Yan Tong, Philip Tonui, Elkanah Orang'o, Jianjun Zhang, Titus Maina, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen, Aaron Ermel
Obstetrics and Gynaecology, East Africa
Background: Cervical cancer is caused by oncogenic human papillomaviruses (HR-HPV) and is common among Kenyan women. Identifcation of factors that increase HR-HPV persistence is critically important. Kenyan women exposed to afatoxin have an increased risk of HR-HPV detection in cervical specimens. This analysis was performed to examine associations between afatoxin and HR-HPV persistence.
Methods: Kenyan women were enrolled in a prospective study. The analytical cohort for this analysis included 67 HIVuninfected women (mean age 34 years) who completed at least two of three annual study visits and had an available blood sample. Plasma afatoxin was detected using ultra-high pressure liquid …
Integrating Human Papillomavirus Testing As A Point-Of Care Service Using Genexpert Platforms: Findings And Lessons From A Kenyan Pilot Study (2019–2020), Valerian Mwenda, Joan-Paula Bor, Mary Nyangasi, James Njeru, Sharon Olwande, Patricia Njiri, Marc Arbyn, Philippe Tummers, Marleen Temmerman
Integrating Human Papillomavirus Testing As A Point-Of Care Service Using Genexpert Platforms: Findings And Lessons From A Kenyan Pilot Study (2019–2020), Valerian Mwenda, Joan-Paula Bor, Mary Nyangasi, James Njeru, Sharon Olwande, Patricia Njiri, Marc Arbyn, Philippe Tummers, Marleen Temmerman
Obstetrics and Gynaecology, East Africa
Background: Globally, cervical cancer is a major public health problem, with about 604,000 new cases and over 340,000 deaths in 2020. In Kenya, it is the leading cause of cancer deaths, with over 3,000 women dying in 2020 alone. Both the Kenyan cancer screening guidelines and the World Health Organization’s Global Cervical Cancer Elimination Strategy recommend human papillomavirus (HPV) testing as the primary screening test. However, HPV testing is not widely available in the public healthcare system in Kenya. We conducted a pilot study using a point of care (POC) HPV test to inform national roll-out.
Methods: The …