Medicine and Health Sciences Commons^™

Potential Role Of Protein Kinase Cbeta In High Fat Diet-Induced Adipose Dysfunction By Regulating Autophagy Levels, Neil Mehta

Williams Honors College, Honors Research Projects

Obesity is the most common nutritional disorder in the United States and worldwide. Public health efforts and other anti-obesity measures clearly have not controlled the obesity epidemic. There is a great need to understand the pathogenic mechanisms underlying fat accumulation. Research of the past decade supports a prominent role for diet-induced adipose tissue dysfunction in the development and/or progression of obesity and associated insulin resistance. Potential mechanisms for the development of adipose tissue dysfunction include ectopic (visceral) fat accumulation, genetic factors, and alterations in autophagy and inflammatory processes. However, the molecular mechanisms linking dietary fat intake with alterations in adipose …