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Articles 1 - 12 of 12

Full-Text Articles in Medicine and Health Sciences

The Role Of Lef1 In Endometrial Gland Formation And Carcinogenesis, Dawne Shelton, Hubert Fornalik, Traci Neff, Soo Park, David Bender, Koen Degeest, Xiaoming Liu, Weiliang Xie, David Meyerholz, John Engelhardt, Michael Goodheart Sep 2013

The Role Of Lef1 In Endometrial Gland Formation And Carcinogenesis, Dawne Shelton, Hubert Fornalik, Traci Neff, Soo Park, David Bender, Koen Degeest, Xiaoming Liu, Weiliang Xie, David Meyerholz, John Engelhardt, Michael Goodheart

David P Bender

No abstract provided.


Metal-Metal Interactions Of Aqueous Lead(Ii) And Tin(Ii) Ions With The Ground-States And Excited-States Of Tetrakis(Mu-Diphosphito)Diplatinate(Ii), David Bender, J. Nagle Apr 2013

Metal-Metal Interactions Of Aqueous Lead(Ii) And Tin(Ii) Ions With The Ground-States And Excited-States Of Tetrakis(Mu-Diphosphito)Diplatinate(Ii), David Bender, J. Nagle

David P Bender

No abstract provided.


Candida Albicans Chorioamnionitis Associated With Preterm Labor And Sudden Intrauterine Demise Of One Twin. A Case Report, U. Friebe-Hoffmann, David Bender, C. Sims, P. Rauk Apr 2013

Candida Albicans Chorioamnionitis Associated With Preterm Labor And Sudden Intrauterine Demise Of One Twin. A Case Report, U. Friebe-Hoffmann, David Bender, C. Sims, P. Rauk

David P Bender

BACKGROUND: Although cervicovaginal Candida infections occur in 20-25% of pregnancies, the incidence of ascending infection in these cases is only 0.8%, and such infection rarely causes chorioamnionitis. CASE: Sudden intrauterine fetal demise (IUFD) of twin A occurred in a diabetic primigravida presenting with a twin pregnancy and preterm labor at 33 weeks of gestation. Placental pathology and autopsy of the stillborn twin revealed extensive chorioamnionitis and fetal sepsis in the presence of Candida albicans. Twin B was unaffected. CONCLUSION: In this case, C albicans chorioamnionitis seemed to be associated with sudden IUFD.


Social Influences On Clinical Outcomes Of Patients With Ovarian Cancer, Susan Lutgendorf, Koen De Geest, David Bender, Amina Ahmed, Michael Goodheart, Laila Dahmoush, M. Zimmerman, Frank Penedo Apr 2013

Social Influences On Clinical Outcomes Of Patients With Ovarian Cancer, Susan Lutgendorf, Koen De Geest, David Bender, Amina Ahmed, Michael Goodheart, Laila Dahmoush, M. Zimmerman, Frank Penedo

David P Bender

PURPOSE Previous research has demonstrated relationships of social support with disease-related biomarkers in patients with ovarian cancer. However, the clinical relevance of these findings to patient outcomes has not been established. This prospective study examined how social support relates to long-term survival among consecutive patients with ovarian cancer. We focused on two types of social support: social attachment, a type of emotional social support reflecting connections with others, and instrumental social support reflecting the availability of tangible assistance. PATIENTS AND METHODS Patients were prospectively recruited during a presurgical clinic visit and completed surveys before surgery. One hundred sixty-eight patients with …


Preoperative Serum Tissue Factor Levels Are An Independent Prognostic Factor In Patients With Ovarian Carcinoma, L. Han, C. Landen, A. Kamat, A. Lopez, David Bender, P. Mueller, R. Schmandt, D. Gershenson, A. Sood Apr 2013

Preoperative Serum Tissue Factor Levels Are An Independent Prognostic Factor In Patients With Ovarian Carcinoma, L. Han, C. Landen, A. Kamat, A. Lopez, David Bender, P. Mueller, R. Schmandt, D. Gershenson, A. Sood

David P Bender

No abstract provided.


Primary Fallopian Tube Cancer - 30 Years Experience At The University Of Iowa, Alireza Shamshirsaz, Michael Goodheart, Gideon Zamba, David Bender, Thomas Buekers, Koen De Geest Apr 2013

Primary Fallopian Tube Cancer - 30 Years Experience At The University Of Iowa, Alireza Shamshirsaz, Michael Goodheart, Gideon Zamba, David Bender, Thomas Buekers, Koen De Geest

David P Bender

No abstract provided.


Luminescent Metal-Metal-Bonded Exciplexes Involving Tetrakis 9(Mu-Diphosphito)Diplatinate(Ii) And Thallium(I), S. Clodfelter, T. Doede, B. Brennan, J. Nagle, David Bender, W. Turner, P. Lapunzina Apr 2013

Luminescent Metal-Metal-Bonded Exciplexes Involving Tetrakis 9(Mu-Diphosphito)Diplatinate(Ii) And Thallium(I), S. Clodfelter, T. Doede, B. Brennan, J. Nagle, David Bender, W. Turner, P. Lapunzina

David P Bender

No abstract provided.


Serum Ca 125 Is An Independent Prognostic Factor In Cervical Adenocarcinoma, David Bender, J. Sorosky, R. Buller, A. Sood Apr 2013

Serum Ca 125 Is An Independent Prognostic Factor In Cervical Adenocarcinoma, David Bender, J. Sorosky, R. Buller, A. Sood

David P Bender

OBJECTIVE: The purpose of this study was to determine the prognostic significance of a pretreatment serum CA 125 value in patients who were diagnosed with adenocarcinoma of the cervix. STUDY DESIGN: All patients who were diagnosed with adenocarcinoma or adenosquamous carcinoma of the cervix and treated definitively between 1986 and 1998 were eligible. The relationship between pretreatment serum CA 125 values and various clinical factors was evaluated. RESULTS: Seventy-three patients had pretreatment CA 125 drawn, with values that ranged from 5 to 683 U/mL and all patients were included in this study. A CA 125 value of >or=30 U/mL was …


A Phase Ii Study Of Vorinostat In The Treatment Of Persistent Or Recurrent Epithelial Ovarian Or Primary Peritoneal Carcinoma: A Gynecologic Oncology Group Study, S. Modesitt, M. Sill, J. Hoffman, David Bender Apr 2013

A Phase Ii Study Of Vorinostat In The Treatment Of Persistent Or Recurrent Epithelial Ovarian Or Primary Peritoneal Carcinoma: A Gynecologic Oncology Group Study, S. Modesitt, M. Sill, J. Hoffman, David Bender

David P Bender

PURPOSE: This multi-institutional phase II trial assessed the activity and toxicity of a new histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamic acid--SAHA) in patients with recurrent or persistent epithelial ovarian or primary peritoneal carcinoma. PATIENTS AND METHODS: Women with recurrent or persistent epithelial ovarian or primary peritoneal carcinoma who were platinum-resistant/refractory (progression-free interval <12 months since platinum) were eligible for trial entry if they had measurable disease, a good performance status, and good overall organ function. Women were treated with a 400 mg daily oral dose of vorinostat and continued on treatment until disease progression or unacceptable toxicity. The primary endpoints …


The Role Of Lymphoid-Enhancing Factor 1 (Lef-1) In Endometrial Gland Morphogenesis, Michael Goodheart, T. Neff, S. Yeun-Park, X. Liu, W. Xie, Koen De Geest, David Bender, T. Buekers, J. Engelhardt Apr 2013

The Role Of Lymphoid-Enhancing Factor 1 (Lef-1) In Endometrial Gland Morphogenesis, Michael Goodheart, T. Neff, S. Yeun-Park, X. Liu, W. Xie, Koen De Geest, David Bender, T. Buekers, J. Engelhardt

David P Bender

No abstract provided.


Intraoperative Autologous Blood Transfusion Use During Radical Hysterectomy For Cervical Cancer: Long-Term Follow-Up Of A Prospective Trial, David Engle, Joseph Connor, Peter Morris, David Bender, Koen De Geest, Amina Ahmed, Michael Goodheart Apr 2013

Intraoperative Autologous Blood Transfusion Use During Radical Hysterectomy For Cervical Cancer: Long-Term Follow-Up Of A Prospective Trial, David Engle, Joseph Connor, Peter Morris, David Bender, Koen De Geest, Amina Ahmed, Michael Goodheart

David P Bender

No abstract provided.


Microvessel Density And P53 Mutations In Advanced-Stage Epithelial Ovarian Cancer, N. J. Nadkarni, Koen De Geest, T. Neff, B. D. Young, D. P. Bender, A. Ahmed, B. J. Smith, A. Button, Michael Goodheart Apr 2013

Microvessel Density And P53 Mutations In Advanced-Stage Epithelial Ovarian Cancer, N. J. Nadkarni, Koen De Geest, T. Neff, B. D. Young, D. P. Bender, A. Ahmed, B. J. Smith, A. Button, Michael Goodheart

David P Bender

We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was elevated in tumors with p53 null mutations compared to p53 missense mutation or no mutation. Disease recurrence was increased with higher MVD in both unadjusted and adjusted analyses. In adjusted analysis, p53 null mutation was associated with increased recurrence and worse overall survival. Worse overall survival and increased recurrence risk were also associated with the combination of …