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Full-Text Articles in Medicine and Health Sciences
Genetic Influence On Resilience To Potentially Traumatic Events, Kosuke Niitsu
Genetic Influence On Resilience To Potentially Traumatic Events, Kosuke Niitsu
Theses & Dissertations
Most individuals experience at least one potentially traumatic event (PTE), such as a natural disaster. When exposed to PTEs, some individuals are more vulnerable to develop psychopathology, such as Post-Traumatic Stress Disorder (PTSD). In contrast, others are less adversely affected by PTEs, who are often described as “resilient”. A concept analysis of resilience (Manuscript #1) revealed: the antecedent is PTE; the defining attributes are ego-resiliency, emotion regulation, heredity, and social support; and the consequences are none to mild psychopathological symptoms and positive adaptation. Based on a systematic review of genetic influence on resilience (Manuscript #2), the following 10 polymorphisms were …
Role Of The Serotonin Transporter Gene In Resilience To Stress And Trauma: An Integrative Review, Kosuke Niitsu
Role Of The Serotonin Transporter Gene In Resilience To Stress And Trauma: An Integrative Review, Kosuke Niitsu
Posters and Presentations: College of Nursing
Resilience is defined as a multi-dimensional dynamic concept of positive adaptation to stress and trauma. It is estimated that 38 - 52% of phenotypic variation in resilience among Americans is due to genetic variance. Among nine candidate genes associated with resilience, the promoter region of serotonin transporter gene (5- HTTLPR) is of increasing clinical interest. Accumulating evidence suggests those who carry the Short (S) allele of 5-HTTLPR may be at increased risk of developing psychopathology such as Post-Traumatic Stress Disorder (PTSD). However, little is known about whether S allele carriers are less resilient to stress and trauma compared to Long …